Cell Biology Antibodies 5
Anti-ADAM28 Antibody (CAB14849)
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- SKU:
- CAB14849
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-ADAM28 Antibody |
| Antibody SKU: | CAB14849 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC |
| Reactivity: | Human, Mouse |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 199-440 of human ADAM28 (NP_055080.2). |
| Application: | WB IHC |
| Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 |
| Reactivity: | Human, Mouse |
| Positive Samples: | SGC-7901, HT-29, THP-1, Mouse liver |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 199-440 of human ADAM28 (NP_055080.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | VQEH EKYI EYYL VLDN GEFK RYNE NQDE IRKR VFEM ANYV NMLY KKLN THVA LVGM EIWT DKDK IKIT PNAS FTLE NFSK WRGS VLSR RKRH DIAQ LITA TELA GTTV GLAF MSTM CSPY SVGV VQDH SDNL LRVA GTMA HEMG HNFG MFHD DYSC KCPS TICV MDKA LSFY IPTD FSSC SRLS YDKF FEDK LSNC LFNA PLPT DIIS TPIC GNQL VEMG EDCD CGTS EECT NICC DAKT CK |
| Gene ID: | 10863 |
| Uniprot: | Q9UKQ2 |
| Cellular Location: | Cell membrane, Secreted, Single-pass type I membrane protein |
| Calculated MW: | 61kDa/87kDa |
| Observed MW: | 87kDa |
| Synonyms: | ADAM28, ADAM 28, MDC-L, MDCL, eMDC II, eMDCII |
| Background: | This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. The protein encoded by this gene is a lymphocyte-expressed ADAM protein. This gene is present in a gene cluster with other members of the ADAM family on chromosome 8. Alternative splicing results in multiple transcript variants. |
| UniProt Protein Function: | ADAM28: May play a role in the adhesive and proteolytic events that occur during lymphocyte emigration or may function in ectodomain shedding of lymphocyte surface target proteins, such as FASL and CD40L. May be involved in sperm maturation. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:EC 3.4.24.-; Membrane protein, integral; Motility/polarity/chemotaxis; Protease Chromosomal Location of Human Ortholog: 8p21.2 Molecular Function:metallopeptidase activity Biological Process: spermatogenesis |
| NCBI Summary: | This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. The protein encoded by this gene is a lymphocyte-expressed ADAM protein. This gene is present in a gene cluster with other members of the ADAM family on chromosome 8. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2015] |
| UniProt Code: | Q9UKQ2 |
| NCBI GenInfo Identifier: | 748983380 |
| NCBI Gene ID: | 10863 |
| NCBI Accession: | NP_001291280.1 |
| UniProt Related Accession: | Q9UKQ2 |
| Molecular Weight: | |
| NCBI Full Name: | disintegrin and metalloproteinase domain-containing protein 28 isoform 4 preproprotein |
| NCBI Synonym Full Names: | ADAM metallopeptidase domain 28 |
| NCBI Official Symbol: | ADAM28 |
| NCBI Official Synonym Symbols: | MDCL; MDC-L; eMDCII; ADAM 28; eMDC II |
| NCBI Protein Information: | disintegrin and metalloproteinase domain-containing protein 28 |
| UniProt Protein Name: | Disintegrin and metalloproteinase domain-containing protein 28 |
| UniProt Synonym Protein Names: | Epididymal metalloproteinase-like, disintegrin-like, and cysteine-rich protein II; eMDC II; Metalloproteinase-like, disintegrin-like, and cysteine-rich protein L; MDC-L |
| UniProt Gene Name: | ADAM28 |
 | Western blot analysis of extracts of various cell lines, using ADAM28 Rabbit pAb (CAB14849) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 5s. |
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