Developmental Biology
Anti-ADCYAP1R1 Antibody (CAB3120)
- SKU:
- CAB3120
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Developmental Biology
Description
| Antibody Name: | Anti-ADCYAP1R1 Antibody |
| Antibody SKU: | CAB3120 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human |
| Host Species: | Rabbit |
| Immunogen: | A synthetic peptide of human ADCYAP1R1 |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human |
| Positive Samples: | HeLa, SH-SY5Y, U-87MG |
| Immunogen: | A synthetic peptide of human ADCYAP1R1 |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 117 |
| Uniprot: | P41586 |
| Cellular Location: | Cell membrane, Multi-pass membrane protein |
| Calculated MW: | 46kDa/51kDa/53kDa/54kDa/56kDa |
| Observed MW: | 60kDa |
| Synonyms: | ADCYAP1R1, PAC1, PAC1R, PACAPR, PACAPRI |
| Background: | This gene encodes type I adenylate cyclase activating polypeptide receptor, which is a membrane-associated protein and shares significant homology with members of the glucagon/secretin receptor family. This receptor mediates diverse biological actions of adenylate cyclase activating polypeptide 1 and is positively coupled to adenylate cyclase. Multiple alternatively spliced transcript variants encoding distinct isoforms have been identified. |
| UniProt Protein Function: | ADCYAP1R1: This is a receptor for PACAP-27 and PACAP-38. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. May regulate the release of adrenocorticotropin, luteinizing hormone, growth hormone, prolactin, epinephrine, and catecholamine. May play a role in spermatogenesis and sperm motility. Causes smooth muscle relaxation and secretion in the gastrointestinal tract. Belongs to the G-protein coupled receptor 2 family. 5 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Receptor, GPCR; Membrane protein, multi-pass; GPCR, family 2; Membrane protein, integral Chromosomal Location of Human Ortholog: 7p14 Cellular Component: neuron projection; cell surface; tight junction; rough endoplasmic reticulum; integral to plasma membrane; plasma membrane; caveola; receptor complex; endosome Molecular Function:ADP-ribosylation factor binding; neuropeptide binding; vasoactive intestinal polypeptide receptor activity; protein binding; receptor activity; adenylate cyclase binding Biological Process: response to drug; G-protein coupled receptor protein signaling pathway; development of primary female sexual characteristics; cAMP-mediated signaling; response to ethanol; cell surface receptor linked signal transduction; nerve growth factor receptor signaling pathway; phospholipase C activation; adenylate cyclase activation; spermatogenesis; cell differentiation; multicellular organismal response to stress; response to estradiol stimulus; transmembrane receptor protein tyrosine kinase signaling pathway |
| NCBI Summary: | This gene encodes type I adenylate cyclase activating polypeptide receptor, which is a membrane-associated protein and shares significant homology with members of the glucagon/secretin receptor family. This receptor mediates diverse biological actions of adenylate cyclase activating polypeptide 1 and is positively coupled to adenylate cyclase. Multiple alternatively spliced transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Dec 2010] |
| UniProt Code: | P41586 |
| NCBI GenInfo Identifier: | 1171986 |
| NCBI Gene ID: | 117 |
| NCBI Accession: | P41586.1 |
| UniProt Related Accession: | P41586 |
| Molecular Weight: | |
| NCBI Full Name: | Pituitary adenylate cyclase-activating polypeptide type I receptor |
| NCBI Synonym Full Names: | ADCYAP receptor type I |
| NCBI Official Symbol: | ADCYAP1R1 |
| NCBI Official Synonym Symbols: | PAC1; PAC1R; PACAPR; PACAPRI |
| NCBI Protein Information: | pituitary adenylate cyclase-activating polypeptide type I receptor |
| UniProt Protein Name: | Pituitary adenylate cyclase-activating polypeptide type I receptor |
| Protein Family: | PACRG-like protein |
| UniProt Gene Name: | ADCYAP1R1 |
| UniProt Entry Name: | PACR_HUMAN |
 | Western blot analysis of extracts of various cell lines, using ADCYAP1R1 antibody (CAB3120) at 1:400 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s. |
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