Cardiovascular Antibodies
Anti-AGGF1 Antibody (CAB8228)
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- SKU:
- CAB8228
- Product Type:
- Antibody
- Applications:
- WB
- Applications:
- IF
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cardiovascular
Description
| Antibody Name: | AGGF1 Rabbit Polyclonal Antibody |
| Antibody SKU: | CAB8228 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IF |
| Reactivity: | Human |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-70 of human AGGF1 (NP_060516.2). |
| Application: | WB IF |
| Recommended Dilution: | WB 1:500 - 1:2000 IF 1:50 - 1:200 |
| Reactivity: | Human |
| Positive Samples: | HeLa, U-251MG |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-70 of human AGGF1 (NP_060516.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MASE APSP PRSP PPPT SPEP ELAQ LRRK VEKL EREL RSCK RQVR EIEK LLHH TERL YQNA ESNN QELR TQ |
| Gene ID: | 55109 |
| Uniprot: | Q8N302 |
| Cellular Location: | Cytoplasm, Secreted |
| Calculated MW: | 12kDa/20kDa/80kDa |
| Observed MW: | 81kDa |
| Synonyms: | AGGF1, GPATC7, GPATCH7, HSU84971, HUS84971, VG5Q |
| Background: | This gene encodes an angiogenic factor that promotes proliferation of endothelial cells. Mutations in this gene are associated with a susceptibility to Klippel-Trenaunay syndrome. Pseudogenes of this gene are found on chromosomes 3, 4, 10 and 16. |
| UniProt Protein Function: | AGGF1: Promotes angiogenesis and the proliferation of endothelial cells. Able to bind to endothelial cells and promote cell proliferation, suggesting that it may act in an autocrine fashion. Defects in AGGF1 are a cause of Klippel-Trenaunay syndrome (KTS). KTS is a congenital disease characterized by malformations of capillary (98% of KTS patients), venous (72%) and lymphatic (11%) vessels, and bony and soft tissue hypertrophy that leads to large cutaneous hemangiomata with hypertrophy of the related bones and soft tissues. 3 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:RNA processing; Cell adhesion Chromosomal Location of Human Ortholog: 5q13.3 Cellular Component: cytoplasm; extracellular region; perinuclear region of cytoplasm Molecular Function:protein binding Biological Process: cell adhesion; positive regulation of angiogenesis; positive regulation of endothelial cell proliferation; RNA processing; vasculogenesis Disease: Klippel-trenaunay-weber Syndrome |
| NCBI Summary: | This gene encodes an angiogenic factor that promotes proliferation of endothelial cells. Mutations in this gene are associated with a susceptibility to Klippel-Trenaunay syndrome. Pseudogenes of this gene are found on chromosomes 3, 4, 10 and 16.[provided by RefSeq, Sep 2010] |
| UniProt Code: | Q8N302 |
| NCBI GenInfo Identifier: | 45477317 |
| NCBI Gene ID: | 55109 |
| NCBI Accession: | Q8N302.2 |
| UniProt Secondary Accession: | Q8N302,O00581, Q53YS3, Q9BU84, Q9NW66, |
| UniProt Related Accession: | Q8N302 |
| Molecular Weight: | 20,506 Da |
| NCBI Full Name: | Angiogenic factor with G patch and FHA domains 1 |
| NCBI Synonym Full Names: | angiogenic factor with G-patch and FHA domains 1 |
| NCBI Official Symbol: | AGGF1 |
| NCBI Official Synonym Symbols: | VG5Q; GPATC7; GPATCH7; HSU84971; HUS84971 |
| NCBI Protein Information: | angiogenic factor with G patch and FHA domains 1 |
| UniProt Protein Name: | Angiogenic factor with G patch and FHA domains 1 |
| UniProt Synonym Protein Names: | Angiogenic factor VG5Q; hVG5Q; G patch domain-containing protein 7; Vasculogenesis gene on 5q protein |
| Protein Family: | Angiogenic factor with G patch and FHA domains |
| UniProt Gene Name: | AGGF1 |
| UniProt Entry Name: | AGGF1_HUMAN |
 | Western blot analysis of extracts of various cell lines, using AGGF1 antibody (CAB8228) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 15s. |
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