Developmental Biology

Anti-AMH Antibody (CAB8538)

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SKU:
CAB8538
Product Type:
Antibody
Applications:
WB
Applications:
IHC
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Developmental Biology

Description

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Antibody Name:Anti-AMH Antibody
Antibody SKU:CAB8538
Antibody Size:20uL, 50uL, 100uL
Application:IHC IF
Reactivity:Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 20-280 of human AMH (NP_000470.2).
Application:IHC IF
Recommended Dilution:IHC 1:50 - 1:100 IF 1:50 - 1:100
Reactivity:Mouse, Rat
Positive Samples:
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 20-280 of human AMH (NP_000470.2).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:LGTE ALRA EEPA VGTS GLIF REDL DWPP GSPQ EPLC LVAL GGDS NGSS SPLR VVGA LSAY EQAF LGAV QRAR WGPR DLAT FGVC NTGD RQAA LPSL RRLG AWLR DPGG QRLV VLHL EEVT WEPT PSLR FQEP PPGG AGPP ELAL LVLY PGPG PEVT VTRA GLPG AQSL CPSR DTRY LVLA VDRP AGAW RGSG LALT LQPR GEDS RLST ARLQ ALLF GDDH RCFT RMTP ALLL LPRS EPAP LPAH GQLD TVPF PPPR PSAE L
Gene ID:268
Uniprot:P03971
Cellular Location:Secreted
Calculated MW:59kDa
Observed MW:Refer to figures
Synonyms:AMH, MIF, MIS
Background:Anti-Mullerian hormone is a member of the transforming growth factor-beta gene family which mediates male sexual differentiation. Anti-Mullerian hormone causes the regression of Mullerian ducts which would otherwise differentiate into the uterus and fallopian tubes. Some mutations in the anti-Mullerian hormone result in persistent Mullerian duct syndrome.
UniProt Protein Function:This glycoprotein, produced by the Sertoli cells of the testis, causes regression of the Muellerian duct. It is also able to inhibit the growth of tumors derived from tissues of Muellerian duct origin.
NCBI Summary:This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate N- and C-terminal cleavage products that homodimerize and associate to form a biologically active noncovalent complex. This complex binds to the anti-Mullerian hormone receptor type 2 and causes the regression of Mullerian ducts in the male embryo that would otherwise differentiate into the uterus and fallopian tubes. This protein also plays a role in Leydig cell differentiation and function and follicular development in adult females. Mutations in this gene result in persistent Mullerian duct syndrome. [provided by RefSeq, Jul 2016]
UniProt Code:P03971
NCBI GenInfo Identifier:313104218
NCBI Gene ID:268
NCBI Accession:P03971.3
UniProt Secondary Accession:P03971,O75246, Q6GTN3,
UniProt Related Accession:P03971
Molecular Weight:
NCBI Full Name:Muellerian-inhibiting factor
NCBI Synonym Full Names:anti-Mullerian hormone
NCBI Official Symbol:AMH  
NCBI Official Synonym Symbols:MIF; MIS  
NCBI Protein Information:muellerian-inhibiting factor
UniProt Protein Name:Muellerian-inhibiting factor
UniProt Synonym Protein Names:Anti-Muellerian hormone; AMH; Muellerian-inhibiting substance; MIS
Protein Family:Muellerian-inhibiting factor
UniProt Gene Name:AMH  
Anti-AMH Polyclonal Antibody (CAB8538)Immunohistochemistry of paraffin-embedded mouse leydig cells using AMH antibody (CAB8538) at dilution of 1:100 (40x lens).
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