Cell Cycle Antibodies 2
Anti-APITD1 Antibody (CAB8293)
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- SKU:
- CAB8293
- Product Type:
- Antibody
- Applications:
- WB
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Cycle
Description
| Antibody Name: | APITD1 Rabbit Polyclonal Antibody |
| Antibody SKU: | CAB8293 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-138 of human APITD1 (NP_954988.1). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human |
| Positive Samples: | U-251MG, SW620, NCI-H460, MCF7, A-549 |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-138 of human APITD1 (NP_954988.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MEEE AETE EQQR FSYQ QRLK AAVH YTVG CLCE EVAL DKEM QFSK QTIA AISE LTFR QCEN FAKD LEMF ARHA KRTT INTE DVKL LARR SNSL LKYI TDKS EEIA QINL ERKA QKKK KSED GSKN SRQP AEAG VVES EN |
| Gene ID: | 378708 |
| Uniprot: | Q8N2Z9 |
| Cellular Location: | Chromosome, Nucleus, centromere, kinetochore |
| Calculated MW: | 9kDa/15kDa/19kDa |
| Observed MW: | 16kDa |
| Synonyms: | CENPS, APITD1, CENP-S, FAAP16, MHF1 |
| Background: | This gene was identified in the neuroblastoma tumor suppressor candidate region on chromosome 1p36. It contains a TFIID-31 domain, similar to that found in TATA box-binding protein-associated factor, TAF(II)31, which is required for p53-mediated transcription activation. This gene was expressed at very low levels in neuroblastoma tumors, and was shown to reduce cell growth in neuroblastoma cells, suggesting that it may have a role in a cell death pathway. The protein is a component of multiple complexes, including the Fanconi anemia (FA) core complex, the APITD1/CENPS complex, and the CENPA-CAD (nucleosome distal) complex. Known functions include an involvement with chromatin associations of the FA core complex, and a role in the stable assembly of the outer kinetochore. Alternative splicing of this gene results in multiple transcript variants. Naturally occurring read-through transcripts also exist between this gene and the downstream cortistatin (CORT) gene, as represented in GeneID:100526739. An APITD1-related pseudogene has been identified on chromosome 7. |
| UniProt Code: | Q8N2Z9 |
| NCBI GenInfo Identifier: | 395394019 |
| NCBI Gene ID: | 100526739 |
| NCBI Accession: | NP_001257446.1 |
| UniProt Secondary Accession: | Q8N2Z9,Q8NFE5, Q8NFG5, |
| Molecular Weight: | 15,893 Da |
| NCBI Full Name: | APITD1-CORT protein isoform 4 |
| NCBI Synonym Full Names: | APITD1-CORT readthrough |
| NCBI Official Symbol: | APITD1-CORT |
| NCBI Protein Information: | APITD1-CORT protein |
| UniProt Protein Name: | Centromere protein S |
| UniProt Synonym Protein Names: | Apoptosis-inducing TAF9-like domain-containing protein 1; FANCM-interacting histone fold protein 1; Fanconi anemia-associated polypeptide of 16 kDa |
| Protein Family: | Centromere protein |
| UniProt Gene Name: | APITD1 |
| UniProt Entry Name: | CENPS_HUMAN |
 | Western blot analysis of extracts of various cell lines, using APITD1 antibody (CAB8293) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 30s. |
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