Developmental Biology
Anti-ASTL Antibody (CAB14984)
- SKU:
- CAB14984
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Developmental Biology
Description
| Antibody Name: | Anti-ASTL Antibody |
| Antibody SKU: | CAB14984 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 24-431 of human ASTL (NP_001002036.3). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human |
| Positive Samples: | Raji |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 24-431 of human ASTL (NP_001002036.3). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | APLA SSCA GACG TSFP DGLT PEGT QASG DKDI PAIN QGLI LEET PESS FLIE GDII RPSP FRLL SATS NKWP MGGS GVVE VPFL LSSK YDEP SRQV ILEA LAEF ERST CIRF VTYQ DQRD FISI IPMY GCFS SVGR SGGM QVVS LAPT CLQK GRGI VLHE LMHV LGFW HEHT RADR DRYI RVNW NEIL PGFE INFI KSQS SNML TPYD YSSV MHYG RLAF SRRG LPTI TPLW APSV HIGQ RWNL SASD ITRV LKLY GCSP SGPR PRGR GSHA HSTG RSPA PASL SLQR LLEA LSAE SRSP DPSG SSAG GQPV PAGP GESP HGWE SPAL KKLS AEAS ARQP QTLA SSPR SRPG AGAP GVAQ EQSW LAGV STKP TVPS SEAG IQPV PVQG SPAL PGGC VPRN HFKG MSED |
| Gene ID: | 431705 |
| Uniprot: | Q6HA08 |
| Cellular Location: | Cell membrane, Cytoplasm, Cytoplasmic granule, Cytoplasmic vesicle, secretory vesicle |
| Calculated MW: | 45kDa |
| Observed MW: | 46kDa |
| Synonyms: | ASTL, SAS1B, MIOX |
| Background: |
| UniProt Protein Function: | ASTL: Oocyte-specific oolemmal receptor involved in sperm and egg adhesion and fertilization. Plays a role in the polyspermy inhibition. Probably acts as a protease for the post-fertilization cleavage of ZP2. Cleaves the sperm-binding ZP2 at the surface of the zona pellucida after fertilization and cortical granule exocytosis, rendering the zona pellucida unable to support further sperm binding. Belongs to the peptidase M12A family. |
| UniProt Protein Details: | Protein type:EC 3.4.-.-; Protease Chromosomal Location of Human Ortholog: 2q11.1 Cellular Component: transport vesicle; cytoplasm; plasma membrane Molecular Function:peptidase activity; zinc ion binding; metalloendopeptidase activity Biological Process: fertilization; proteolysis; cell adhesion |
| UniProt Code: | Q6HA08 |
| NCBI GenInfo Identifier: | 157502169 |
| NCBI Gene ID: | 431705 |
| NCBI Accession: | NP_001002036.3 |
| UniProt Secondary Accession: | Q6HA08,Q3KNT0, |
| UniProt Related Accession: | Q6HA08 |
| Molecular Weight: | 45,936 Da |
| NCBI Full Name: | astacin-like metalloendopeptidase |
| NCBI Synonym Full Names: | astacin-like metallo-endopeptidase (M12 family) |
| NCBI Official Symbol: | ASTL |
| NCBI Official Synonym Symbols: | SAS1B |
| NCBI Protein Information: | astacin-like metalloendopeptidase; ovastacin; oocyte astacin; sperm acrosomal SLLP1 binding; astacin-like metalloendopeptidase (M12 family) |
| UniProt Protein Name: | Astacin-like metalloendopeptidase |
| UniProt Synonym Protein Names: | Oocyte astacin; Ovastacin |
| Protein Family: | Astacin-like metalloendopeptidase |
| UniProt Gene Name: | ASTL |
| UniProt Entry Name: | ASTL_HUMAN |
 | Western blot analysis of extracts of Raji cells, using ASTL antibody (CAB14984) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 60s. |
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