Autophagy Antibodies
Anti-ATG10 Antibody (CAB6848)
- SKU:
- CAB6848
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Autophagy
Description
| Antibody Name: | Anti-ATG10 Antibody |
| Antibody SKU: | CAB6848 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IF |
| Reactivity: | Human, Mouse |
| Host Species: | Rabbit |
| Immunogen: | A synthesized peptide derived from human ATG10 |
| Application: | WB IF |
| Recommended Dilution: | WB 1:500 - 1:2000 IF 1:50 - 1:200 |
| Reactivity: | Human, Mouse |
| Positive Samples: | HeLa, 293T, K-562, SH-SY5Y, Mouse heart |
| Immunogen: | A synthesized peptide derived from human ATG10 |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 83734 |
| Uniprot: | Q9H0Y0 |
| Cellular Location: | Cytoplasm |
| Calculated MW: | 25kDa |
| Observed MW: | 28KDa |
| Synonyms: | APG10, APG10L, pp12616 |
| Background: | Autophagy is a process for the bulk degradation of cytosolic compartments by lysosomes. ATG10 is an E2-like enzyme involved in 2 ubiquitin-like modifications essential for autophagosome formation: ATG12 (MIM 609608)-ATG5 (MIM 604261) conjugation and modification of a soluble form of MAP-LC3 (MAP1LC3A; MIM 601242), a homolog of yeast Apg8, to a membrane-bound form (Nemoto et al., 2003 [PubMed 12890687]).[supplied by OMIM, Mar 2008] |
| UniProt Protein Function: | ATG10: E2-like enzyme involved in autophagy. Acts as an E2-like enzyme that catalyzes the conjugation of ATG12 to ATG5. ATG12 conjugation to ATG5 is required for autophagy. Likely serves as an ATG5-recognition molecule. Not involved in ATG12 conjugation to ATG3. Belongs to the ATG10 family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:EC 6.3.2.-; Autophagy; Ubiquitin conjugating system Chromosomal Location of Human Ortholog: 5q14.1 Cellular Component: cytosol; intracellular Molecular Function:APG12 conjugating enzyme activity Biological Process: autophagy; macroautophagy; positive regulation of protein modification process; protein amino acid lipidation; protein modification by small protein conjugation |
| NCBI Summary: | Autophagy is a process for the bulk degradation of cytosolic compartments by lysosomes. ATG10 is an E2-like enzyme involved in 2 ubiquitin-like modifications essential for autophagosome formation: ATG12 (MIM 609608)-ATG5 (MIM 604261) conjugation and modification of a soluble form of MAP-LC3 (MAP1LC3A; MIM 601242), a homolog of yeast Apg8, to a membrane-bound form (Nemoto et al., 2003 [PubMed 12890687]).[supplied by OMIM, Mar 2008] |
| UniProt Code: | Q9H0Y0 |
| NCBI GenInfo Identifier: | 62286633 |
| NCBI Gene ID: | 83734 |
| NCBI Accession: | Q9H0Y0.1 |
| UniProt Secondary Accession: | Q9H0Y0,Q6PIX1, Q9H842, B2RE09, |
| UniProt Related Accession: | Q9H0Y0 |
| Molecular Weight: | 14,217 Da |
| NCBI Full Name: | Ubiquitin-like-conjugating enzyme ATG10 |
| NCBI Synonym Full Names: | autophagy related 10 |
| NCBI Official Symbol: | ATG10 |
| NCBI Official Synonym Symbols: | APG10; APG10L; pp12616 |
| NCBI Protein Information: | ubiquitin-like-conjugating enzyme ATG10 |
| UniProt Protein Name: | Ubiquitin-like-conjugating enzyme ATG10 |
| UniProt Synonym Protein Names: | Autophagy-related protein 10; APG10-like |
| Protein Family: | Ubiquitin-like-conjugating enzyme |
| UniProt Gene Name: | ATG10 |
| UniProt Entry Name: | ATG10_HUMAN |
 | Western blot - ATG10 Rabbit mAb (CAB6848) |
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