Cardiovascular Antibodies
Anti-CHD2 Antibody (CAB13476)
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- SKU:
- CAB13476
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cardiovascular
Description
| Antibody Name: | Anti-CHD2 Antibody |
| Antibody SKU: | CAB13476 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | IF |
| Reactivity: | Human |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 242-501 of human CHD2 (NP_001036037.1). |
| Application: | IF |
| Recommended Dilution: | IF 1:50 - 1:200 |
| Reactivity: | Human |
| Positive Samples: |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 242-501 of human CHD2 (NP_001036037.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | SDDL IEMT GEGV DEQQ DNSE TIEK VLDS RLGK KGAT GAST TVYA IEAN GDPS GDFD TEKD EGEI QYLI KWKG WSYI HSTW ESEE SLQQ QKVK GLKK LENF KKKE DEIK QWLG KVSP EDVE YFNC QQEL ASEL NKQY QIVE RVIA VKTS KSTL GQTD FPAH SRKP APSN EPEY LCKW MGLP YSEC SWED EALI GKKF QNCI DSFH SRNN SKTI PTRE CKAL KQRP RFVA LKKQ PAYL GGEN LELR DYQL EGLN WLAH SWCK |
| Gene ID: | 1106 |
| Uniprot: | O14647 |
| Cellular Location: | Nucleus |
| Calculated MW: | 56kDa/200kDa/211kDa |
| Observed MW: |
| Synonyms: | CHD2, EEOC |
| Background: | The CHD family of proteins is characterized by the presence of chromo (chromatin organization modifier) domains and SNF2-related helicase/ATPase domains. CHD genes alter gene expression possibly by modification of chromatin structure thus altering access of the transcriptional apparatus to its chromosomal DNA template. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. |
| UniProt Protein Function: | CHD-2: Sequence-selective DNA-binding protein. Belongs to the SNF2/RAD54 helicase family. 3 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:EC 3.6.4.12; Helicase; DNA-binding Chromosomal Location of Human Ortholog: 15q26 Cellular Component: nucleoplasm; intracellular membrane-bound organelle; nucleolus; nucleus Molecular Function:ATP-dependent DNA helicase activity; DNA binding; histone binding; ATP binding Biological Process: regulation of transcription from RNA polymerase II promoter; muscle development; transcription, DNA-dependent; chromatin modification; response to DNA damage stimulus; DNA duplex unwinding Disease: Epileptic Encephalopathy, Childhood-onset |
| NCBI Summary: | The CHD family of proteins is characterized by the presence of chromo (chromatin organization modifier) domains and SNF2-related helicase/ATPase domains. CHD genes alter gene expression possibly by modification of chromatin structure thus altering access of the transcriptional apparatus to its chromosomal DNA template. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008] |
| UniProt Code: | O14647 |
| NCBI GenInfo Identifier: | 119370320 |
| NCBI Gene ID: | 1106 |
| NCBI Accession: | O14647.2 |
| UniProt Secondary Accession: | O14647,Q96IP5, C6G482, |
| UniProt Related Accession: | O14647 |
| Molecular Weight: | 1828 |
| NCBI Full Name: | Chromodomain-helicase-DNA-binding protein 2 |
| NCBI Synonym Full Names: | chromodomain helicase DNA binding protein 2 |
| NCBI Official Symbol: | CHD2 |
| NCBI Official Synonym Symbols: | EEOC |
| NCBI Protein Information: | chromodomain-helicase-DNA-binding protein 2; CHD-2; ATP-dependent helicase CHD2 |
| UniProt Protein Name: | Chromodomain-helicase-DNA-binding protein 2 |
| UniProt Synonym Protein Names: | ATP-dependent helicase CHD2 |
| Protein Family: | Chromodomain-helicase-DNA-binding protein |
| UniProt Gene Name: | CHD2 |
| UniProt Entry Name: | CHD2_HUMAN |
 | Immunofluorescence analysis of HeLa cells using CHD2 antibody (CAB13476). Blue: DAPI for nuclear staining. |
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