Developmental Biology
Anti-CHD5 Antibody (CAB8578)
- SKU:
- CAB8578
- Product Type:
- Antibody
- Applications:
- WB
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Developmental Biology
Description
| Antibody Name: | Anti-CHD5 Antibody |
| Antibody SKU: | CAB8578 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1530-1700 of human CHD5 (NP_056372.1). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human |
| Positive Samples: | MCF7 |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1530-1700 of human CHD5 (NP_056372.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | IPEG PEGK KSGE VISS DPNT PVPA SPAH LLPA PLGL PDKM EAQL GYMD EKDP GAQK PRQP LEVQ ALPA ALDR VESE DKHE SPAS KERA REER PEET EKAP PSPE QLPR EEVL PEKE KILD KLEL SLIH SRGD SSEL RPDD TKAE EKEP IETQ QNGD KEED DEGK KEDK KGK |
| Gene ID: | 26038 |
| Uniprot: | Q8TDI0 |
| Cellular Location: | Nucleus |
| Calculated MW: | 223kDa |
| Observed MW: | 223kDa |
| Synonyms: | CHD5, CHD-5 |
| Background: | This gene encodes a member of the chromodomain helicase DNA-binding protein family. Members of this family are characterized by a chromodomain, a helicase ATP-binding domain and an additional functional domain. This gene encodes a neuron-specific protein that may function in chromatin remodeling and gene transcription. This gene is a potential tumor suppressor gene that may play a role in the development of neuroblastoma. |
| UniProt Protein Function: | CHD-5: May play a role in the development of the nervous system and the pathogenesis of neural tumors. Belongs to the SNF2/RAD54 helicase family. |
| UniProt Protein Details: | Protein type:EC 3.6.4.12; DNA-binding; Tumor suppressor; Helicase Chromosomal Location of Human Ortholog: 1p36.31 Cellular Component: heterochromatin; membrane; nucleus; NuRD complex Biological Process: cerebral cortex neuron differentiation; negative regulation of cell proliferation; spermatogenesis, exchange of chromosomal proteins |
| NCBI Summary: | This gene encodes a member of the chromodomain helicase DNA-binding protein family. Members of this family are characterized by a chromodomain, a helicase ATP-binding domain and an additional functional domain. This gene encodes a neuron-specific protein that may function in chromatin remodeling and gene transcription. This gene is a potential tumor suppressor gene that may play a role in the development of neuroblastoma. [provided by RefSeq, Feb 2012] |
| UniProt Code: | Q8TDI0 |
| NCBI GenInfo Identifier: | 51701343 |
| NCBI Gene ID: | 26038 |
| NCBI Accession: | Q8TDI0.1 |
| UniProt Secondary Accession: | Q8TDI0,O75032, Q5TG89, Q7LGH2, Q9UFR9, |
| UniProt Related Accession: | Q8TDI0 |
| Molecular Weight: | 223,050 Da |
| NCBI Full Name: | Chromodomain-helicase-DNA-binding protein 5 |
| NCBI Synonym Full Names: | chromodomain helicase DNA binding protein 5 |
| NCBI Official Symbol: | CHD5 |
| NCBI Official Synonym Symbols: | CHD-5 |
| NCBI Protein Information: | chromodomain-helicase-DNA-binding protein 5 |
| UniProt Protein Name: | Chromodomain-helicase-DNA-binding protein 5 |
| UniProt Synonym Protein Names: | ATP-dependent helicase CHD5 |
| Protein Family: | Chromodomain-helicase-DNA-binding protein |
| UniProt Gene Name: | CHD5 |
| UniProt Entry Name: | CHD5_HUMAN |
 | Western blot analysis of extracts of MCF-7 cells, using CHD5 antibody (CAB8578) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (RM00021). Exposure time: 10s. |
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