Cardiovascular Antibodies
Anti-CPB2 Antibody (CAB5634)
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- SKU:
- CAB5634
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cardiovascular
Description
| Antibody Name: | Anti-CPB2 Antibody |
| Antibody SKU: | CAB5634 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 115-365 of human CPB2 (NP_001863.2). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human |
| Positive Samples: | 293T, NCI-H460 |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 115-365 of human CPB2 (NP_001863.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | ASAS YYEQ YHSL NEIY SWIE FITE RHPD MLTK IHIG SSFE KYPL YVLK VSGK EQAA KNAI WIDC GIHA REWI SPAF CLWF IGHI TQFY GIIG QYTN LLRL VDFY VMPV VNVD GYDY SWKK NRMW RKNR SFYA NNHC IGTD LNRN FASK HWCE EGAS SSSC SETY CGLY PESE PEVK AVAS FLRR NINQ IKAY ISMH SYSQ HIVF PYSY TRSK SKDH EELS LVAS EAVR AIEK TSKN TRYT HGHG SETL YLA |
| Gene ID: | 1361 |
| Uniprot: | Q96IY4 |
| Cellular Location: | Secreted |
| Calculated MW: | 40kDa/48kDa |
| Observed MW: | 47kDa |
| Synonyms: | CPB2, CPU, PCPB, TAFI |
| Background: | Carboxypeptidases are enzymes that hydrolyze C-terminal peptide bonds. The carboxypeptidase family includes metallo-, serine, and cysteine carboxypeptidases. According to their substrate specificity, these enzymes are referred to as carboxypeptidase A (cleaving aliphatic residues) or carboxypeptidase B (cleaving basic amino residues). The protein encoded by this gene is activated by trypsin and acts on carboxypeptidase B substrates. After thrombin activation, the mature protein downregulates fibrinolysis. Polymorphisms have been described for this gene and its promoter region. Alternate splicing results in multiple transcript variants. |
| UniProt Protein Function: | CPB2: Cleaves C-terminal arginine or lysine residues from biologically active peptides such as kinins or anaphylatoxins in the circulation thereby regulating their activities. Down- regulates fibrinolysis by removing C-terminal lysine residues from fibrin that has already been partially degraded by plasmin. Belongs to the peptidase M14 family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:EC 3.4.17.20; Secreted, signal peptide; Secreted; Protease Chromosomal Location of Human Ortholog: 13q14.11 Cellular Component: extracellular space Molecular Function:zinc ion binding; metallocarboxypeptidase activity Biological Process: response to drug; fibrinolysis; negative regulation of fibrinolysis; response to heat; blood coagulation; proteolysis |
| NCBI Summary: | Carboxypeptidases are enzymes that hydrolyze C-terminal peptide bonds. The carboxypeptidase family includes metallo-, serine, and cysteine carboxypeptidases. According to their substrate specificity, these enzymes are referred to as carboxypeptidase A (cleaving aliphatic residues) or carboxypeptidase B (cleaving basic amino residues). The protein encoded by this gene is activated by trypsin and acts on carboxypeptidase B substrates. After thrombin activation, the mature protein downregulates fibrinolysis. Polymorphisms have been described for this gene and its promoter region. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jun 2013] |
| UniProt Code: | Q96IY4 |
| NCBI GenInfo Identifier: | 317373332 |
| NCBI Gene ID: | 1361 |
| NCBI Accession: | Q96IY4.2 |
| UniProt Secondary Accession: | Q96IY4,Q15114, Q5T9K1, Q5T9K2, Q9P2Y6, A8K464, |
| UniProt Related Accession: | Q96IY4 |
| Molecular Weight: | 423 |
| NCBI Full Name: | Carboxypeptidase B2 |
| NCBI Synonym Full Names: | carboxypeptidase B2 (plasma) |
| NCBI Official Symbol: | CPB2 |
| NCBI Official Synonym Symbols: | CPU; PCPB; TAFI |
| NCBI Protein Information: | carboxypeptidase B2; carboxypeptidase R; carboxypeptidase B-like protein; thrombin-activable fibrinolysis inhibitor; thrombin-activatable fibrinolysis inhibitor; carboxypeptidase B2 (plasma, carboxypeptidase U) |
| UniProt Protein Name: | Carboxypeptidase B2 |
| UniProt Synonym Protein Names: | Carboxypeptidase U; CPU; Plasma carboxypeptidase B; pCPB; Thrombin-activable fibrinolysis inhibitor; TAFI |
| Protein Family: | Carboxypeptidase |
| UniProt Gene Name: | CPB2 |
| UniProt Entry Name: | CBPB2_HUMAN |
 | Western blot analysis of extracts of various cell lines, using CPB2 Antibody (CAB5634) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (RM00021). Exposure time: 30s. |
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