Anti-CYP26A1 Antibody (CAB5982)
- SKU:
- CAB5982
- Product Type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Synonyms:
- CP26
- Synonyms:
- CYP26
- Synonyms:
- P450RAI
- Synonyms:
- P450RAI1
Description
| Product Name: | CYP26A1 Rabbit mAb |
| Product Code: | CAB5982 |
| Size: | 20uL, 50uL, 100uL |
| Synonyms: | CP26, CYP26, P450RAI, P450RAI1 |
| Applications: | WB, IHC, IF |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | A synthesized peptide derived from human CYP26A1 |
| Applications: | WB, IHC, IF |
| Recommended Dilutions: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | Rat liver |
| Immunogen: | A synthesized peptide derived from human CYP26A1 |
| Purification Method: | Affinity purification |
| Storage: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 1592 |
| Uniprot: | O43174 |
| Calculated MW: | 50kDa |
| Observed MW: | 56KDa |
| UniProt Protein Function: | CYP26A1: Plays a key role in retinoic acid metabolism. Acts on retinoids, including all-trans-retinoic acid (RA) and its stereoisomer 9-cis-RA. Capable of both 4-hydroxylation and 18- hydroxylation. Responsible for generation of several hydroxylated forms of RA, including 4-OH-RA, 4-oxo-RA and 18-OH-RA. Belongs to the cytochrome P450 family. |
| UniProt Protein Details: | Protein type:Cofactor and Vitamin Metabolism - retinol; EC 1.14.-.-; Oxidoreductase; Endoplasmic reticulum Chromosomal Location of Human Ortholog: 10q23-q24 Cellular Component: endoplasmic reticulum membrane Molecular Function:oxygen binding; retinoic acid 4-hydroxylase activity; retinoic acid binding Biological Process: metabolic process; negative regulation of retinoic acid receptor signaling pathway; vitamin metabolic process |
| NCBI Summary: | This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This endoplasmic reticulum protein acts on retinoids, including all-trans-retinoic acid (RA), with both 4-hydroxylation and 18-hydroxylation activities. This enzyme regulates the cellular level of retinoic acid which is involved in regulation of gene expression in both embryonic and adult tissues. Two alternatively spliced transcript variants of this gene, which encode the distinct isoforms, have been reported. [provided by RefSeq, Jul 2008] |
| UniProt Code: | O43174 |
| NCBI GenInfo Identifier: | 218511987 |
| NCBI Gene ID: | 1592 |
| NCBI Accession: | O43174.2 |
| UniProt Secondary Accession: | O43174,Q5VXH9, Q5VXI0, B3KNI4, |
| UniProt Related Accession: | O43174 |
| Molecular Weight: | 48,558 Da |
| NCBI Full Name: | Cytochrome P450 26A1 |
| NCBI Synonym Full Names: | cytochrome P450 family 26 subfamily A member 1 |
| NCBI Official Symbol: | CYP26A1 |
| NCBI Official Synonym Symbols: | CP26; CYP26; P450RAI; P450RAI1 |
| NCBI Protein Information: | cytochrome P450 26A1 |
| UniProt Protein Name: | Cytochrome P450 26A1 |
| UniProt Synonym Protein Names: | Cytochrome P450 retinoic acid-inactivating 1; Cytochrome P450RAI; hP450RAI; Retinoic acid 4-hydroxylase; Retinoic acid-metabolizing cytochrome |
| Protein Family: | Cytochrome |
| UniProt Gene Name: | CYP26A1 |
| UniProt Entry Name: | CP26A_HUMAN |
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