Developmental Biology
Anti-DBN1 Antibody (CAB6366)
- SKU:
- CAB6366
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Developmental Biology
Description
| Antibody Name: | Anti-DBN1 Antibody |
| Antibody SKU: | CAB6366 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IF |
| Reactivity: | Human |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 350-649 of human DBN1 (NP_004386.2). |
| Application: | WB IF |
| Recommended Dilution: | WB 1:500 - 1:2000 IF 1:50 - 1:100 |
| Reactivity: | Human |
| Positive Samples: | BT-474, HeLa, SKOV3 |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 350-649 of human DBN1 (NP_004386.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | EQIE RALD EVTS SQPP PLPP PPPP AQET QEPS PILD SEET RAAA PQAW AGPM EEPP QAQA PPRG PGSP AEDL MFME SAEQ AVLA APVE PATA DATE IHDA ADTI ETDT ATAD TTVA NNVP PAAT SLID LWPG NGEG ASTL QGEP RAPT PPSG TEVT LAEV PLLD EVAP EPLL PAGE GCAT LLNF DELP EPPA TFCD PEEV EGEP LAAP QTPT LPSA LEEL EQEQ EPEP HLLT NGET TQKE GTQA SEGY FSQS QEEE FAQS EELC AKAP PPVF YNKP PEID ITCW DADP VPEE EEGF EGGD |
| Gene ID: | 1627 |
| Uniprot: | Q16643 |
| Cellular Location: | Cell junction, Cell projection, Cytoplasm, cell cortex, growth cone |
| Calculated MW: | 71kDa/76kDa |
| Observed MW: | 110kDa |
| Synonyms: | DBN1, D0S117E, drebrin |
| Background: | The protein encoded by this gene is a cytoplasmic actin-binding protein thought to play a role in the process of neuronal growth. It is a member of the drebrin family of proteins that are developmentally regulated in the brain. A decrease in the amount of this protein in the brain has been implicated as a possible contributing factor in the pathogenesis of memory disturbance in Alzheimer's disease. At least two alternative splice variants encoding different protein isoforms have been described for this gene. |
| UniProt Protein Function: | DBN1: a cytoplasmic actin-binding protein thought to play a role in the process of neuronal growth. It is a member of the drebrin family of proteins that are developmentally regulated in the brain. A decrease in the amount of this protein in the brain has been implicated as a possible contributing factor in the pathogenesis of memory disturbance in Alzheimer's disease. Expressed in brain neurons, heart, placenta, skeletal muscle, kidney and pancreas. Two alternatively spliced isoforms have been described. |
| UniProt Protein Details: | Protein type:Motility/polarity/chemotaxis; Actin-binding; Cytoskeletal Chromosomal Location of Human Ortholog: 5q35.3 Cellular Component: actin cytoskeleton; growth cone; plasma membrane Molecular Function:profilin binding; protein binding Biological Process: actin filament organization |
| NCBI Summary: | The protein encoded by this gene is a cytoplasmic actin-binding protein thought to play a role in the process of neuronal growth. It is a member of the drebrin family of proteins that are developmentally regulated in the brain. A decrease in the amount of this protein in the brain has been implicated as a possible contributing factor in the pathogenesis of memory disturbance in Alzheimer's disease. At least two alternative splice variants encoding different protein isoforms have been described for this gene. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q16643 |
| NCBI GenInfo Identifier: | 215274247 |
| NCBI Gene ID: | 1627 |
| NCBI Accession: | Q16643.4 |
| UniProt Secondary Accession: | Q16643,Q9UFZ5, A8MV58, B2RBG0, |
| UniProt Related Accession: | Q16643 |
| Molecular Weight: | 76,300 Da |
| NCBI Full Name: | Drebrin |
| NCBI Synonym Full Names: | drebrin 1 |
| NCBI Official Symbol: | DBN1 |
| NCBI Official Synonym Symbols: | D0S117E |
| NCBI Protein Information: | drebrin |
| UniProt Protein Name: | Drebrin |
| UniProt Synonym Protein Names: | Developmentally-regulated brain protein |
| Protein Family: | Drebrin |
| UniProt Gene Name: | DBN1 |
| UniProt Entry Name: | DREB_HUMAN |
 | Western blot analysis of extracts of various cell lines, using DBN1 antibody (CAB6366) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s. |
 | Immunofluorescence analysis of HeLa cells using DBN1 antibody (CAB6366). Blue: DAPI for nuclear staining. |
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