Cardiovascular Antibodies
Anti-DLL4 Antibody (CAB12943)
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- SKU:
- CAB12943
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cardiovascular
Description
| Antibody Name: | Anti-DLL4 Antibody |
| Antibody SKU: | CAB12943 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 317-530 of human DLL4 (NP_061947.1). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | A-431, Rat kidney |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 317-530 of human DLL4 (NP_061947.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | TGVD CELE LSEC DSNP CRNG GSCK DQED GYHC LCPP GYYG LHCE HSTL SCAD SPCF NGGS CRER NQGA NYAC ECPP NFTG SNCE KKVD RCTS NPCA NGGQ CLNR GPSR MCRC RPGF TGTY CELH VSDC ARNP CAHG GTCH DLEN GLMC TCPA GFSG RRCE VRTS IDAC ASSP CFNR ATCY TDLS TDTF VCNC PYGF VGSR CEFP VGLP PSFP WV |
| Gene ID: | 54567 |
| Uniprot: | Q9NR61 |
| Cellular Location: | Membrane, Single-pass type I membrane protein |
| Calculated MW: | 74kDa |
| Observed MW: | 75kDa |
| Synonyms: | DLL4, AOS6, hdelta2 |
| Background: | This gene is a homolog of the Drosophila delta gene. The delta gene family encodes Notch ligands that are characterized by a DSL domain, EGF repeats, and a transmembrane domain. |
| UniProt Protein Function: | DLL4: Plays a role in the Notch signaling pathway. Activates Notch-1 and Notch-4. Binds to Notch-1 and Notch-4. Expressed in vascular endothelium. |
| UniProt Protein Details: | Protein type:Cell development/differentiation; Membrane protein, integral Chromosomal Location of Human Ortholog: 15q15.1 Cellular Component: plasma membrane Molecular Function:protein binding Biological Process: angiogenesis; blood circulation; blood vessel remodeling; negative regulation of cell proliferation; negative regulation of Notch signaling pathway; negative regulation of transcription from RNA polymerase II promoter; Notch receptor processing; Notch signaling pathway; patterning of blood vessels; positive regulation of Notch signaling pathway; signal transduction; T cell differentiation Disease: Adams-oliver Syndrome 6 |
| NCBI Summary: | This gene is a homolog of the Drosophila delta gene. The delta gene family encodes Notch ligands that are characterized by a DSL domain, EGF repeats, and a transmembrane domain. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q9NR61 |
| NCBI GenInfo Identifier: | 13431490 |
| NCBI Gene ID: | 54567 |
| NCBI Accession: | Q9NR61.1 |
| UniProt Secondary Accession: | Q9NR61,Q3KP23, Q9NQT9, |
| UniProt Related Accession: | Q9NR61 |
| Molecular Weight: | 75kDa |
| NCBI Full Name: | Delta-like protein 4 |
| NCBI Synonym Full Names: | delta like canonical Notch ligand 4 |
| NCBI Official Symbol: | DLL4 |
| NCBI Official Synonym Symbols: | AOS6; hdelta2 |
| NCBI Protein Information: | delta-like protein 4 |
| UniProt Protein Name: | Delta-like protein 4 |
| UniProt Synonym Protein Names: | Drosophila Delta homolog 4; Delta4 |
| Protein Family: | Delta-like protein |
| UniProt Gene Name: | DLL4 |
 | Western blot analysis of extracts of various cell lines, using DLL4 antibody (CAB12943) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s. |
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