Developmental Biology
Anti-DNMT3L Antibody (CAB13591)
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- SKU:
- CAB13591
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Developmental Biology
Description
| Antibody Name: | Anti-DNMT3L Antibody |
| Antibody SKU: | CAB13591 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 151-386 of human DNMT3L (NP_787063.1). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse |
| Positive Samples: | HeLa, Jurkat, Mouse thymus, Mouse ovary |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 151-386 of human DNMT3L (NP_787063.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | SGLL QRRR KWRS QLKA FYDR ESEN PLEM FETV PVWR RQPV RVLS LFED IKKE LTSL GFLE SGSD PGQL KHVV DVTD TVRK DVEE WGPF DLVY GATP PLGH TCDR PPSW YLFQ FHRL LQYA RPKP GSPR PFFW MFVD NLVL NKED LDVA SRFL EMEP VTIP DVHG GSLQ NAVR VWSN IPAI RSRH WALV SEEE LSLL AQNK QSSK LAAK WPTK LVKN CFLP LREY FKYF STEL TSSL |
| Gene ID: | 29947 |
| Uniprot: | Q9UJW3 |
| Cellular Location: | Nucleus |
| Calculated MW: | 43kDa |
| Observed MW: | 45kDa |
| Synonyms: | DNMT3L |
| Background: | CpG methylation is an epigenetic modification that is important for embryonic development, imprinting, and X-chromosome inactivation. Studies in mice have demonstrated that DNA methylation is required for mammalian development. This gene encodes a nuclear protein with similarity to DNA methyltransferases, but is not thought to function as a DNA methyltransferase as it does not contain the amino acid residues necessary for methyltransferase activity. However, it does stimulate de novo methylation by DNA cytosine methyltransferase 3 alpha and is thought to be required for the establishment of maternal genomic imprints. This protein also mediates transcriptional repression through interaction with histone deacetylase 1. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. |
| UniProt Code: | Q9UJW3 |
| NCBI GenInfo Identifier: | 334302913 |
| NCBI Gene ID: | 29947 |
| NCBI Accession: | Q9UJW3.3 |
| Molecular Weight: | 45kDa |
| NCBI Full Name: | DNA (cytosine-5)-methyltransferase 3-like |
| UniProt Protein Name: | DNA (cytosine-5)-methyltransferase 3-like |
| Protein Family: | DNA (cytosine-5)-methyltransferase |
| UniProt Gene Name: | DNMT3L |
| UniProt Entry Name: | DNM3L_HUMAN |
 | Western blot analysis of extracts of various cell lines, using DNMT3L antibody (CAB13591) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 30s. |
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