Cardiovascular Antibodies

Anti-EPHB4 Antibody (CAB3293)

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SKU:
CAB3293
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Cardiovascular

Description

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Antibody Name:Anti-EPHB4 Antibody
Antibody SKU:CAB3293
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human, Mouse
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 300-540 of human EPHB4 (NP_004435.3).
Application:WB
Recommended Dilution:WB 1:200 - 1:2000
Reactivity:Human, Mouse
Positive Samples:Mouse liver
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 300-540 of human EPHB4 (NP_004435.3).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:AVCQ CRVG YFRA RTDP RGAP CTTP PSAP RSVV SRLN GSSL HLEW SAPL ESGG REDL TYAL RCRE CRPG GSCA PCGG DLTF DPGP RDLV EPWV VVRG LRPD FTYT FEVT ALNG VSSL ATGP VPFE PVNV TTDR EVPP AVSD IRVT RSSP SSLS LAWA VPRA PSGA VLDY EVKY HEKG AEGP SSVR FLKT SENR AELR GLKR GASY LVQV RARS EAGY GPFG QEHH SQTQ LDES EGWR EQLA L
Gene ID:2050
Uniprot:P54760
Cellular Location:Cell membrane, Single-pass type I membrane protein
Calculated MW:108kDa
Observed MW:108kDa
Synonyms:EPHB4, HFASD, HTK, MYK1, TYRO11
Background:Ephrin receptors and their ligands, the ephrins, mediate numerous developmental processes, particularly in the nervous system. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. The Eph family of receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. Ephrin receptors make up the largest subgroup of the receptor tyrosine kinase (RTK) family. The protein encoded by this gene binds to ephrin-B2 and plays an essential role in vascular development.
NCBI Summary:Ephrin receptors and their ligands, the ephrins, mediate numerous developmental processes, particularly in the nervous system. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. The Eph family of receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. Ephrin receptors make up the largest subgroup of the receptor tyrosine kinase (RTK) family. The protein encoded by this gene binds to ephrin-B2 and plays an essential role in vascular development. [provided by RefSeq, Jul 2008]
UniProt Code:P54760
NCBI GenInfo Identifier:495473
NCBI Gene ID:2050
NCBI Accession:
UniProt Related Accession:P54760
Molecular Weight:
NCBI Full Name:tyrosine kinase
NCBI Synonym Full Names:EPH receptor B4
NCBI Official Symbol:EPHB4  
NCBI Official Synonym Symbols:HTK; MYK1; HFASD; CMAVM2; LMPHM7; TYRO11  
NCBI Protein Information:ephrin type-B receptor 4
UniProt Protein Name:
UniProt Gene Name:
Anti-EPHB4 Antibody (CAB3293)Western blot analysis of extracts of mouse liver, using EPHB4 antibody (CAB3293) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s.
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