Cardiovascular Antibodies
Anti-FAP1 Antibody (CAB11572)
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- SKU:
- CAB11572
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Monoclonal Antibody
- Research Area:
- Cardiovascular
Description
| Antibody Name: | Anti-FAP1 Antibody |
| Antibody SKU: | CAB11572 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human |
| Host Species: | Rabbit |
| Immunogen: | A synthesized peptide derived from human FAP1 |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human |
| Positive Samples: | U-87MG |
| Immunogen: | A synthesized peptide derived from human FAP1 |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 2191 |
| Uniprot: | Q12884 |
| Cellular Location: | |
| Calculated MW: | 95kDa |
| Observed MW: | 88KDa |
 | Western blot - FAP1 Rabbit mAb (CAB11572) |
| Synonyms: | DPPIV, FAPA, FAPalpha, SIMP |
| Background: | The protein encoded by this gene is a homodimeric integral membrane gelatinase belonging to the serine protease family. It is selectively expressed in reactive stromal fibroblasts of epithelial cancers, granulation tissue of healing wounds, and malignant cells of bone and soft tissue sarcomas. This protein is thought to be involved in the control of fibroblast growth or epithelial-mesenchymal interactions during development, tissue repair, and epithelial carcinogenesis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2014] |
| UniProt Protein Function: | FAP: In association with DPP4 is involved in the pericellular proteolysis of the extracellular matrix (ECM), the migration and invasion of endothelial cells into the ECM. May have a role in tissue remodeling during development and wound healing, and may contribute to invasiveness in malignant cancers. Belongs to the peptidase S9B family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:EC 3.4.14.5; Protease; EC 3.4.21.26; Membrane protein, integral Chromosomal Location of Human Ortholog: 2q23 Cellular Component: apical part of cell; cell surface; cytoplasm; extracellular space; focal adhesion; integral to membrane; lamellipodium; plasma membrane Molecular Function:dipeptidyl-peptidase activity; endopeptidase activity; integrin binding; metalloendopeptidase activity; peptidase activity; protease binding; protein binding; protein dimerization activity; protein homodimerization activity; serine-type endopeptidase activity; serine-type peptidase activity Biological Process: angiogenesis; cell adhesion; endothelial cell migration; proteolysis; proteolysis involved in cellular protein catabolic process; regulation of fibrinolysis |
| NCBI Summary: | The protein encoded by this gene is a homodimeric integral membrane gelatinase belonging to the serine protease family. It is selectively expressed in reactive stromal fibroblasts of epithelial cancers, granulation tissue of healing wounds, and malignant cells of bone and soft tissue sarcomas. This protein is thought to be involved in the control of fibroblast growth or epithelial-mesenchymal interactions during development, tissue repair, and epithelial carcinogenesis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2014] |
| UniProt Code: | Q12884 |
| NCBI GenInfo Identifier: | 292495099 |
| NCBI Gene ID: | 2191 |
| NCBI Accession: | Q12884.5 |
| UniProt Secondary Accession: | Q12884,O00199, Q53TP5, Q86Z29, Q99998, Q9UID4, |
| UniProt Related Accession: | Q12884 |
| Molecular Weight: | |
| NCBI Full Name: | Prolyl endopeptidase FAP |
| NCBI Synonym Full Names: | fibroblast activation protein alpha |
| NCBI Official Symbol: | FAP |
| NCBI Official Synonym Symbols: | FAPA; SIMP; DPPIV |
| NCBI Protein Information: | prolyl endopeptidase FAP |
| UniProt Protein Name: | Prolyl endopeptidase FAP |
| UniProt Synonym Protein Names: | 170 kDa melanoma membrane-bound gelatinase |
| Protein Family: | Prolyl endopeptidase |
| UniProt Gene Name: | FAP |
| UniProt Entry Name: | SEPR_HUMAN |
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