Anti-IRF6 Antibody (CAB3209)
- SKU:
- CAB3209
- Product Type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Synonyms:
- LPS
- Synonyms:
- OFC6
- Synonyms:
- PIT
- Synonyms:
- PPS
- Synonyms:
- PPS1
- Synonyms:
- VWS
- Synonyms:
- VWS1
- Research Area:
- Developmental Biology
Description
| Product Name: | IRF6 Rabbit mAb |
| Product Code: | CAB3209 |
| Size: | 20uL, 50uL, 100uL |
| Synonyms: | LPS, OFC6, PIT, PPS, PPS1, VWS, VWS1 |
| Applications: | WB, IF, IP |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | A synthesized peptide derived from human IRF6 |
| Applications: | WB, IF, IP |
| Recommended Dilutions: | WB 1:500 - 1:2000 IF 1:50 - 1:200 IP 1:50 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | 293T, HepG2, A-549, Mouse lung, Mouse kidney, Rat lung, Rat liver |
| Immunogen: | A synthesized peptide derived from human IRF6 |
| Purification Method: | Affinity purification |
| Storage: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 3664 |
| Uniprot: | O14896 |
| Cellular Location: | Cytoplasm, Nucleus |
| Calculated MW: | 53kDa |
| Observed MW: | 68kDa |
| UniProt Protein Function: | IRF6: Probable DNA-binding transcriptional activator. Key determinant of the keratinocyte proliferation-differentiation switch involved in appropriate epidermal development. Plays a role in regulating mammary epithelial cell proliferation. May regulate WDR65 transcription. Interacts with SERPINB5. Expressed in normal mammary epithelial cells. Expression is reduced or absent in breast carcinomas. Belongs to the IRF family. |
| UniProt Protein Details: | Protein type:Transcription factor; DNA-binding Chromosomal Location of Human Ortholog: 1q32.3-q41 Cellular Component: cytoplasm; cytosol; nucleus Molecular Function:protein binding; DNA binding; transcription factor activity Biological Process: keratinocyte differentiation; negative regulation of cell proliferation; transcription, DNA-dependent; positive regulation of transcription, DNA-dependent; cytokine and chemokine mediated signaling pathway; keratinocyte proliferation; cell cycle arrest; cell development Disease: Orofacial Cleft 6, Susceptibility To; Popliteal Pterygium Syndrome; Van Der Woude Syndrome 1 |
| NCBI Summary: | This gene encodes a member of the interferon regulatory transcription factor (IRF) family. Family members share a highly-conserved N-terminal helix-turn-helix DNA-binding domain and a less conserved C-terminal protein-binding domain. The encoded protein may be a transcriptional activator. Mutations in this gene can cause van der Woude syndrome and popliteal pterygium syndrome. Mutations in this gene are also associated with non-syndromic orofacial cleft type 6. Alternate splicing results in multiple transcript variants.[provided by RefSeq, May 2011] |
| UniProt Code: | O14896 |
| NCBI GenInfo Identifier: | 3122293 |
| NCBI Gene ID: | 3664 |
| NCBI Accession: | O14896.1 |
| UniProt Secondary Accession: | O14896,B4DLE2, D3DT90, F5GWX8, G0ZTL0, |
| UniProt Related Accession: | O14896 |
| Molecular Weight: | 467 |
| NCBI Full Name: | Interferon regulatory factor 6 |
| NCBI Synonym Full Names: | interferon regulatory factor 6 |
| NCBI Official Symbol: | IRF6 |
| NCBI Official Synonym Symbols: | LPS; PIT; PPS; VWS; OFC6; PPS1; VWS1 |
| NCBI Protein Information: | interferon regulatory factor 6 |
| UniProt Protein Name: | Interferon regulatory factor 6 |
| Protein Family: | Interferon regulatory factor |
| UniProt Gene Name: | IRF6 |
| UniProt Entry Name: | IRF6_HUMAN |
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