Anti-LEFTY1/2 Antibody (CAB2387)
- SKU:
- CAB2387
- Product Type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Synonyms:
- LEFTB
- Synonyms:
- LEFTYB
- Research Area:
- Autophagy
Description
| Product Name: | LEFTY1/2 Rabbit mAb |
| Product Code: | CAB2387 |
| Size: | 20uL, 50uL, 100uL |
| Synonyms: | LEFTB, LEFTYB |
| Applications: | WB, IHC |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | A synthesized peptide derived from human LEFTY1/2 |
| Applications: | WB, IHC |
| Recommended Dilutions: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | HT-29, BxPC-3, Mouse brain, Rat brain |
| Immunogen: | A synthesized peptide derived from human LEFTY1/2 |
| Purification Method: | Affinity purification |
| Storage: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 10637/7044 |
| Uniprot: | O75610/O00292 |
| Calculated MW: | 34.44kDa |
| Observed MW: | 41KDa |
| UniProt Protein Function: | LEFTY1: Required for left-right axis determination as a regulator of LEFTY2 and NODAL. Belongs to the TGF-beta family. |
| UniProt Protein Details: | Protein type:Cytokine; Ligand, receptor tyrosine kinase; Motility/polarity/chemotaxis; Secreted, signal peptide; Secreted Chromosomal Location of Human Ortholog: 1q42.1 Cellular Component: extracellular space Molecular Function:cytokine activity; transforming growth factor beta receptor binding Biological Process: cell development; determination of left/right symmetry; heart morphogenesis; negative regulation of transcription from RNA polymerase II promoter; regulation of apoptosis; regulation of MAPKKK cascade; transforming growth factor beta receptor signaling pathway |
| NCBI Summary: | This gene encodes a member of the TGF-beta family of proteins. A similar secreted protein in mouse plays a role in left-right asymmetry determination of organ systems during development. Alternative processing of this protein can yield three different products. This gene is closely linked to both a related family member and a related pseudogene. [provided by RefSeq, Jul 2008] |
| UniProt Code: | O75610 |
| NCBI GenInfo Identifier: | 13124321 |
| NCBI Gene ID: | 10637 |
| NCBI Accession: | O75610.1 |
| UniProt Secondary Accession: | O75610,Q53H67, Q5TE94, B2R7U0, |
| UniProt Related Accession: | O75610 |
| Molecular Weight: | 40,880 Da |
| NCBI Full Name: | Left-right determination factor 1 |
| NCBI Synonym Full Names: | left-right determination factor 1 |
| NCBI Official Symbol: | LEFTY1 |
| NCBI Official Synonym Symbols: | LEFTB; LEFTYB |
| NCBI Protein Information: | left-right determination factor 1 |
| UniProt Protein Name: | Left-right determination factor 1 |
| UniProt Synonym Protein Names: | Left-right determination factor B; Protein lefty-1; Protein lefty-B |
| Protein Family: | Left-right determination factor |
| UniProt Gene Name: | LEFTY1 |
| UniProt Entry Name: | LFTY1_HUMAN |
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