Autophagy Antibodies
Anti-Phospho-ATG13-Ser355 Antibody (CABP1089)
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- SKU:
- CABP1089
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Autophagy
Description
| Antibody Name: | Anti-Phospho-ATG13-Ser355 Antibody |
| Antibody SKU: | CABP1089 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | A phospho synthetic peptide corresponding to residues surrounding Ser355 of human ATG13. |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | C6 |
| Immunogen: | A phospho synthetic peptide corresponding to residues surrounding Ser355 of human ATG13. |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 9776 |
| Uniprot: | O75143 |
| Cellular Location: | Cytoplasm, Preautophagosomal structure, cytosol |
| Calculated MW: | 44kDa/52kDa/56kDa/60kDa |
| Observed MW: | 60kDa |
 | Western blot - Phospho-ATG13-Ser355 Rabbit pAb (CABP1089) |
| Synonyms: | KIAA0652, PARATARG8, ATG13 |
| Background: | The protein encoded by this gene is an autophagy factor and a target of the TOR kinase signaling pathway. The encoded protein is essential for autophagosome formation and mitophagy. [provided by RefSeq, Oct 2016] |
| UniProt Protein Function: | ATG13: an autophagy factor required for autophagosome formation. Target of the TOR kinase signaling pathway that regulates autophagy through the control of the phosphorylation status of ATG13 and ULK1, and the regulation of the ATG13-ULK1-RB1CC1 complex. Under starvation conditions, is localized to puncate structures primarily representing the isolation membrane; the isolation membrane sequesters a portion of the cytoplasm resulting in autophagosome formation. Phosphorylated by ULK1 and ULK2. Phosphorylation status depends on nutrient-rich conditions; dephosphorylated during starvation or following treatment with rapamycin. Part of a complex consisting of ATG13, ULK1 and RB1CC1. Interacts with ATG101. Interacts with ULK1 and -2 via C-terminus. Three isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Vesicle; Autophagy Chromosomal Location of Human Ortholog: 11p11.2 Cellular Component: mitochondrion; cytosol Molecular Function:protein binding; protein kinase binding Biological Process: autophagic vacuole formation |
| NCBI Summary: | The protein encoded by this gene is an autophagy factor and a target of the TOR kinase signaling pathway. The encoded protein is essential for autophagosome formation and mitophagy. [provided by RefSeq, Oct 2016] |
| UniProt Code: | O75143 |
| NCBI GenInfo Identifier: | 20140441 |
| NCBI Gene ID: | 9776 |
| NCBI Accession: | O75143.1 |
| UniProt Related Accession: | O75143 |
| Molecular Weight: | Observed: 57 kDaPredicted: 57 kDa |
| NCBI Full Name: | Autophagy-related protein 13 |
| NCBI Synonym Full Names: | autophagy related 13 |
| NCBI Official Symbol: | ATG13 |
| NCBI Official Synonym Symbols: | KIAA0652; PARATARG8 |
| NCBI Protein Information: | autophagy-related protein 13 |
| UniProt Protein Name: | Autophagy-related protein 13 |
| Protein Family: | Autophagy protein |
| UniProt Gene Name: | ATG13 |
| UniProt Entry Name: | ATG13_HUMAN |
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