Anti-Phospho-Cdc6-S54 Antibody (CABP1153)

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SKU:
CABP1153
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Human
Reactivity:
Mouse
Host Species:
Rabbit
Isotype:
IgG
Synonyms:
CDC18L
Synonyms:
HsCDC18
Synonyms:
HsCDC6
Synonyms:
MGORS5
Research Area:
Cell Cycle

Description

Product Name:Phospho-Cdc6-S54 Rabbit mAb
Product Code:CABP1153
Size:20uL, 50uL, 100uL
Synonyms:CDC18L, HsCDC18, HsCDC6, MGORS5
Applications:WB
Reactivity:Human, Mouse,
Host Species:Rabbit
Immunogen:A phospho specific peptide corresponding to residues surrounding S54 of human Cdc6
Applications:WB
Recommended Dilutions:WB 1:500 - 1:2000
Reactivity:Human, Mouse,
Positive Samples:NIH/3T3
Immunogen:A phospho specific peptide corresponding to residues surrounding S54 of human Cdc6
Purification Method:Affinity purification
Storage:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:990
Uniprot:Q99741
Cellular Location:Cytoplasm, Nucleus
Calculated MW:63kDa
Observed MW:63kDa
UniProt Protein Function:CDC6: Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated. Interacts with PCNA, ORC1L, cyclin-CDK and HUWE1. Belongs to the CDC6/cdc18 family.
UniProt Protein Details:

Protein type:Cell cycle regulation

Chromosomal Location of Human Ortholog: 17q21.3

Cellular Component: cytoplasm; cytosol; Golgi apparatus; nucleoplasm; nucleus; spindle midzone; spindle pole

Molecular Function:kinase binding; nucleotide binding; protein binding

Biological Process: DNA replication; DNA replication checkpoint; G1/S transition of mitotic cell cycle; G1/S-specific transcription in mitotic cell cycle; negative regulation of cell proliferation; negative regulation of DNA replication; positive regulation of chromosome segregation; positive regulation of cytokinesis; regulation of cyclin-dependent protein kinase activity; regulation of mitotic metaphase/anaphase transition; traversing start control point of mitotic cell cycle

Disease: Meier-gorlin Syndrome 5

NCBI Summary:The protein encoded by this gene is highly similar to Saccharomyces cerevisiae Cdc6, a protein essential for the initiation of DNA replication. This protein functions as a regulator at the early steps of DNA replication. It localizes in cell nucleus during cell cyle G1, but translocates to the cytoplasm at the start of S phase. The subcellular translocation of this protein during cell cyle is regulated through its phosphorylation by Cdks. Transcription of this protein was reported to be regulated in response to mitogenic signals through transcriptional control mechanism involving E2F proteins. [provided by RefSeq, Jul 2008]
UniProt Code:Q99741
NCBI GenInfo Identifier:50400620
NCBI Gene ID:990
NCBI Accession:Q99741.1
UniProt Secondary Accession:Q99741,Q8TB30,
UniProt Related Accession:Q99741
Molecular Weight:62,720 Da
NCBI Full Name:Cell division control protein 6 homolog
NCBI Synonym Full Names:cell division cycle 6
NCBI Official Symbol:CDC6  
NCBI Official Synonym Symbols:CDC18L; HsCDC6; HsCDC18  
NCBI Protein Information:cell division control protein 6 homolog
UniProt Protein Name:Cell division control protein 6 homolog
UniProt Synonym Protein Names:CDC6-related protein; Cdc18-related protein; HsCdc18; p62(cdc6); HsCDC6
Protein Family:Cell division control protein
UniProt Gene Name:CDC6  
UniProt Entry Name:CDC6_HUMAN
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