Anti-Phospho-CENPA-S7 Antibody (CABP1183)

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SKU:
CABP1183
Product Type:
Antibody
Antibody Type:
Polyclonal Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Synonyms:
CENP-A
Synonyms:
CenH3
Research Area:
Cell Cycle

Description

Product Name:Phospho-CENPA-S7 Rabbit pAb
Product Code:CABP1183
Size:20uL, 50uL, 100uL
Synonyms:CENP-A, CenH3
Applications:WB
Reactivity:Human
Host Species:Rabbit
Immunogen:A synthetic phosphorylated peptide around S7 of human CENPA (NP_001035891.1).
Applications:WB
Recommended Dilutions:WB 1:500 - 1:2000
Reactivity:Human
Immunogen:A synthetic phosphorylated peptide around S7 of human CENPA (NP_001035891.1).
Purification Method:Affinity purification
Storage:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:1058
Uniprot:P49450
Observed MW:Refer to figures
UniProt Protein Function:CENPA: a basic nuclear protein of the histone H3 family. May act as a core histone necessary for the assembly of centromeres. Contains a histone H3 related histone fold domain that is required for targeting to the centromere. CENPA is proposed to be a component of a modified nucleosome or nucleosome-like structure in which it replaces 1 or both copies of conventional histone H3 in the (H3-H4)2 tetrameric core of the nucleosome particle.
UniProt Protein Details:

Protein type:DNA-binding

Chromosomal Location of Human Ortholog: 2p23.3

Cellular Component: chromosome, pericentric region; condensed nuclear chromosome, pericentric region; cytosol; nucleoplasm; nucleus

Molecular Function:chromatin binding; protein binding

Biological Process: DNA replication-independent nucleosome assembly at centromere; establishment of mitotic spindle orientation; kinetochore assembly; sister chromatid cohesion

NCBI Summary:Centromeres are the differentiated chromosomal domains that specify the mitotic behavior of chromosomes. This gene encodes a centromere protein which contains a histone H3 related histone fold domain that is required for targeting to the centromere. Centromere protein A is proposed to be a component of a modified nucleosome or nucleosome-like structure in which it replaces 1 or both copies of conventional histone H3 in the (H3-H4)2 tetrameric core of the nucleosome particle. The protein is a replication-independent histone that is a member of the histone H3 family. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Nov 2015]
UniProt Code:P49450
NCBI GenInfo Identifier:1345726
NCBI Gene ID:1058
NCBI Accession:P49450.1
UniProt Secondary Accession:P49450,Q53T74, Q9BVW2, D6W544,
UniProt Related Accession:P49450
Molecular Weight:13,001 Da
NCBI Full Name:Histone H3-like centromeric protein A
NCBI Synonym Full Names:centromere protein A
NCBI Official Symbol:CENPA  
NCBI Official Synonym Symbols:CenH3; CENP-A  
NCBI Protein Information:histone H3-like centromeric protein A
UniProt Protein Name:Histone H3-like centromeric protein A
UniProt Synonym Protein Names:Centromere autoantigen A; Centromere protein A; CENP-A
Protein Family:Histone H3-like centromeric protein
UniProt Gene Name:CENPA  
UniProt Entry Name:CENPA_HUMAN
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