Anti-Phospho-PLA2G4A-S505 Antibody (CABP0968)

(No reviews yet) Write a Review
SKU:
CABP0968
Product Type:
Antibody
Antibody Type:
Polyclonal Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Synonyms:
PLA2G4A
Synonyms:
PLA2G4
Synonyms:
cPLA2
Synonyms:
cPLA2-alpha
Research Area:
Metabolism

Description

Product Name:Phospho-PLA2G4A-S505 Rabbit pAb
Product Code:CABP0968
Size:20uL, 50uL, 100uL
Synonyms:PLA2G4A, PLA2G4, cPLA2, cPLA2-alpha
Applications:WB
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:A synthetic phosphorylated peptide around of human Phospho-PLA2G4A-S505.
Applications:WB
Recommended Dilutions:WB 1:500 - 1:2000
Reactivity:Human, Mouse, Rat
Positive Samples:NIH/3T3
Immunogen:A synthetic phosphorylated peptide around of human Phospho-PLA2G4A-S505.
Purification Method:Affinity purification
Storage:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:5321
Uniprot:P47712
Cellular Location:Cytoplasm, Cytoplasmic vesicle
Calculated MW:85kDa
Observed MW:Refer to figures
UniProt Protein Function:cPLA2: a calcium-dependent phospholipase A2 that catalyzes the release of arachidonic acid from membrane phospholipids. Selectively hydrolyzes arachidonyl phospholipids in the sn-2 position releasing arachidonic acid. Arachidonic acid is a precursor for the eicosanoids that are involved in hemodynamic regulation, inflammatory responses, and other cellular processes. Promotes cerebellar long-term depression and motor learning. Translocates to the Golgi and endoplasmic reticulum in a calcium-dependent fashion. Translocation and activation of at the ER facilitates the process of ER stress. Regulates the biogenesis of lipid droplets, a process dependent on JNK and ceramide kinase. Stimulated by agonists such as ATP, EGF, thrombin and bradykinin as well as by cytosolic Ca2+. The N-terminal C2 domain, by its association with lipid membranes, mediates the regulation of CPLA2 by presenting the active site to its substrate in response to elevations of cytosolic Ca2+. Inhibited when in trimolecular complex with ANXA2 and S100A10. Phosphorylation of S727 relieves this inhibitory interaction, thus activating PLA2G4A.
UniProt Protein Details:

Protein type:Lipid Metabolism - linoleic acid; Lipid Metabolism - ether lipid; Lipid Metabolism - glycerophospholipid; EC 3.1.1.4; Lipid Metabolism - alpha-linolenic acid; Phospholipase; EC 3.1.1.5; Lipid Metabolism - arachidonic acid

Chromosomal Location of Human Ortholog: 1q25

Cellular Component: Golgi apparatus; endoplasmic reticulum membrane; mitochondrial inner membrane; cytoplasmic membrane-bound vesicle; cytoplasm; cytosol

Molecular Function:phospholipase A2 activity; calcium-dependent phospholipase A2 activity; calcium-dependent phospholipid binding; calcium ion binding; lysophospholipase activity

Biological Process: icosanoid biosynthetic process; platelet activating factor biosynthetic process; platelet activation; phospholipid catabolic process; phospholipid metabolic process; glycerophospholipid biosynthetic process; icosanoid metabolic process; arachidonic acid metabolic process; phosphatidic acid biosynthetic process; arachidonic acid secretion; blood coagulation; regulation of cell proliferation

NCBI Summary:This gene encodes a member of the cytosolic phospholipase A2 group IV family. The enzyme catalyzes the hydrolysis of membrane phospholipids to release arachidonic acid which is subsequently metabolized into eicosanoids. Eicosanoids, including prostaglandins and leukotrienes, are lipid-based cellular hormones that regulate hemodynamics, inflammatory responses, and other intracellular pathways. The hydrolysis reaction also produces lysophospholipids that are converted into platelet-activating factor. The enzyme is activated by increased intracellular Ca(2+) levels and phosphorylation, resulting in its translocation from the cytosol and nucleus to perinuclear membrane vesicles. [provided by RefSeq, Jul 2008]
UniProt Code:P47712
NCBI GenInfo Identifier:317373312
NCBI Gene ID:5321
NCBI Accession:P47712.2
UniProt Secondary Accession:P47712,Q29R80, B1AKG4,
UniProt Related Accession:P47712
Molecular Weight:85,239 Da
NCBI Full Name:Cytosolic phospholipase A2
NCBI Synonym Full Names:phospholipase A2, group IVA (cytosolic, calcium-dependent)
NCBI Official Symbol:PLA2G4A  
NCBI Official Synonym Symbols:PLA2G4; cPLA2-alpha  
NCBI Protein Information:cytosolic phospholipase A2; cPLA2; lysophospholipase; phospholipase A2 group IVA; phosphatidylcholine 2-acylhydrolase; calcium-dependent phospholipid-binding protein
UniProt Protein Name:Cytosolic phospholipase A2
UniProt Synonym Protein Names:Phospholipase A2 group IVAIncluding the following 2 domains:Phospholipase A2 (EC:3.1.1.4)Alternative name(s):Phosphatidylcholine 2-acylhydrolase
Protein Family:Phospholipase
UniProt Gene Name:PLA2G4A  
UniProt Entry Name:PA24A_HUMAN
View AllClose

0 Reviews

View AllClose

Related Products