Anti-Phospho-RIP3-S227 Antibody (CABP1257)
- SKU:
- CABP1257
- Product Type:
- Antibody
- Antibody Type:
- Polyclonal Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Synonyms:
- RIPK3
- Synonyms:
- RIP3
- Research Area:
- Cell Biology
Description
| Product Name: | Phospho-RIP3-S227 Rabbit pAb |
| Product Code: | CABP1257 |
| Size: | 50uL, 100uL |
| Synonyms: | RIPK3, RIP3 |
| Applications: | WB |
| Reactivity: | Human |
| Host Species: | Rabbit |
| Immunogen: | A phospho synthetic peptide corresponding to residues surrounding S227 of Human RIP3. |
| Applications: | WB |
| Recommended Dilutions: | WB 1:500 - 1:2000 |
| Reactivity: | Human |
| Immunogen: | A phospho synthetic peptide corresponding to residues surrounding S227 of Human RIP3. |
| Purification Method: | Affinity purification |
| Storage: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 11035 |
| Uniprot: | Q9Y572 |
| Cellular Location: | Cell membrane, Cytoplasm, Mitochondrion, cytosol |
| Calculated MW: | 25kDa/27kDa/56kDa |
| Observed MW: | Refer to figures |
| UniProt Protein Function: | RIPK3: Promotes apoptosis. Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. Binds TRAF2 and RIPK1 and is recruited to the TNFR-1 signaling complex. 3 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:EC 2.7.11.1; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL; Kinase, protein; TKL group; RIPK family Chromosomal Location of Human Ortholog: 14q11.2 Cellular Component: mitochondrion; plasma membrane; cytosol Molecular Function:NF-kappaB-inducing kinase activity; protein serine/threonine kinase activity; identical protein binding; protein binding; transcription coactivator activity; protein complex binding; ATP binding; protein kinase activity Biological Process: spleen development; I-kappaB kinase/NF-kappaB cascade; regulation of activated T cell proliferation; thymus development; protein heterooligomerization; protein amino acid autophosphorylation; MyD88-independent toll-like receptor signaling pathway; T cell differentiation in the thymus; protein modification process; toll-like receptor 3 signaling pathway; signal transduction; lymph node development; activation of NF-kappaB transcription factor; regulation of T cell mediated cytotoxicity; regulation of adaptive immune response; regulation of interferon-gamma production; toll-like receptor signaling pathway; positive regulation of interferon type I production; activation of protein kinase activity; innate immune response; T cell homeostasis; positive regulation of ligase activity; toll-like receptor 4 signaling pathway; protein homooligomerization; positive regulation of oxidoreductase activity |
| UniProt Code: | Q9Y572 |
| NCBI GenInfo Identifier: | 40254844 |
| NCBI Gene ID: | 11035 |
| NCBI Accession: | NP_006862 |
| UniProt Secondary Accession: | Q9Y572,Q5J795, Q5J796, Q6P5Y1, B4DJL9, C4AM87, |
| UniProt Related Accession: | Q9Y572 |
| Molecular Weight: | 25,326 Da |
| NCBI Full Name: | receptor-interacting serine/threonine-protein kinase 3 |
| NCBI Synonym Full Names: | receptor-interacting serine-threonine kinase 3 |
| NCBI Official Symbol: | RIPK3 |
| NCBI Official Synonym Symbols: | RIP3 |
| NCBI Protein Information: | receptor-interacting serine/threonine-protein kinase 3; RIP-3; RIP-like protein kinase 3; receptor interacting protein 3; receptor-interacting protein 3 |
| UniProt Protein Name: | Receptor-interacting serine/threonine-protein kinase 3 |
| UniProt Synonym Protein Names: | RIP-like protein kinase 3; Receptor-interacting protein 3; RIP-3 |
| Protein Family: | Putative zinc metalloprotease |
| UniProt Gene Name: | RIPK3 |
| UniProt Entry Name: | RIPK3_HUMAN |
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