Anti-Phospho-VANGL2-S11/S14 Antibody (CABP1203)

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SKU:
CABP1203
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Human
Reactivity:
Mouse
Host Species:
Rabbit
Isotype:
IgG
Synonyms:
VANGL2
Synonyms:
LPP1
Synonyms:
LTAP
Synonyms:
STB1
Synonyms:
STBM
Synonyms:
STBM1
Research Area:
Cell Biology

Description

Product Name:Phospho-VANGL2-S11/S14 Rabbit mAb
Product Code:CABP1203
Size:20uL, 50uL, 100uL
Synonyms:VANGL2, LPP1, LTAP, STB1, STBM, STBM1
Applications:WB
Reactivity:Human, Mouse
Host Species:Rabbit
Immunogen:A phospho specific peptide corresponding to residues surrounding S11/S14 of human VANGL2
Applications:WB
Recommended Dilutions:WB 1:500 - 1:2000
Reactivity:Human, Mouse
Immunogen:A phospho specific peptide corresponding to residues surrounding S11/S14 of human VANGL2
Purification Method:Affinity purification
Storage:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:57216
Uniprot:Q9ULK5
Cellular Location:Cell membrane, Multi-pass membrane protein
Calculated MW:59kDa
Observed MW:Refer to figures
UniProt Protein Function:VANGL2: Involved in the control of early morphogenesis and patterning of both axial midline structures and the development of neural plate. Plays a role in the regulation of planar cell polarity, particularly in the orientation of stereociliary bundles in the cochlea. Required for polarization and movement of myocardializing cells in the outflow tract and seems to act via RHOA signaling to regulate this process. Interacts through its C-terminal region with the N- terminal half of DVL1, DVL2 and DVL3. The PDZ domain of DVL1, DVL2 and DVL3 is required for the interaction. Also interacts with the PDZ domains of MAGI3, SCRIB/SCRB1 and FZD3. Belongs to the Vang family.
UniProt Protein Details:

Protein type:Adaptor/scaffold; Membrane protein, integral; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 1q22-q23

Cellular Component: apical plasma membrane; intercellular junction; lateral plasma membrane; plasma membrane

Molecular Function:protein binding

Biological Process: apical protein localization; establishment of planar polarity; heart looping; neural tube closure; sensory cilium biogenesis

Disease: Neural Tube Defects

NCBI Summary:The protein encoded by this gene is a membrane protein involved in the regulation of planar cell polarity, especially in the stereociliary bundles of the cochlea. The encoded protein transmits directional signals to individual cells or groups of cells in epithelial sheets. This protein is also involved in the development of the neural plate. [provided by RefSeq, Sep 2011]
UniProt Code:Q9ULK5
NCBI GenInfo Identifier:38258849
NCBI Gene ID:57216
NCBI Accession:Q9ULK5.2
UniProt Secondary Accession:Q9ULK5,Q5T212, D3DVE9,
UniProt Related Accession:Q9ULK5
Molecular Weight:59,714 Da
NCBI Full Name:Vang-like protein 2
NCBI Synonym Full Names:VANGL planar cell polarity protein 2
NCBI Official Symbol:VANGL2  
NCBI Official Synonym Symbols:LPP1; LTAP; STB1; STBM; STBM1  
NCBI Protein Information:vang-like protein 2
UniProt Protein Name:Vang-like protein 2
UniProt Synonym Protein Names:Loop-tail protein 1 homolog; Strabismus 1; Van Gogh-like protein 2
Protein Family:Vang-like protein
UniProt Gene Name:VANGL2  
UniProt Entry Name:VANG2_HUMAN
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