Autophagy Antibodies
Anti-Protein CLEC16A Antibody (CAB9753)
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- SKU:
- CAB9753
- Product Type:
- Antibody
- Applications:
- WB
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Autophagy
Description
| Antibody Name: | Anti-Protein CLEC16A Antibody |
| Antibody SKU: | CAB9753 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 330-550 of human CLEC16A (NP_001230332.1). |
| Application: | WB |
| Recommended Dilution: | WB 1:200 - 1:2000 |
| Reactivity: | Human |
| Positive Samples: | B cells, U-87MG, 293T, LO2 |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 330-550 of human CLEC16A (NP_001230332.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | SLAE VILN GDLS EMYA KTEQ DIQR SSAK PSIR CFIK PTET LERS LEMN KHKG KRRV QKRP NYKN VGEE EDEE KGPT EDAQ EDAE KAKE IEMV IMER SKLS ELAA STSV QEQN TTDE EKSA AATC SEST QWSR PFLD MVYH ALDS PDDD YHAL FVLC LLYA MSHN KGMD PEKL ERIQ LPVP NAAE KTTY NHPL AERL IRIM NNAA QPDG KIRL ATLE LSCL L |
| Gene ID: | 23274 |
| Uniprot: | Q2KHT3 |
| Cellular Location: | Endosome membrane, Lysosome membrane, Peripheral membrane protein |
| Calculated MW: | 14kDa/103kDa/117kDa |
| Observed MW: | 118kDa |
| Synonyms: | CLEC16A, Gop-1, KIAA0350 |
| Background: | This gene encodes a member of the C-type lectin domain containing family. Single nucleotide polymorphisms in introns of this gene have been associated with diabetes mellitus, multiple sclerosis and rheumatoid arthritis. Multiple transcript variants encoding different isoforms have been found for this gene. |
| UniProt Protein Function: | CLEC16A: Insulin-dependent diabetes mellitus is significantly associated with variation within a 233-kb linkage disequilibrium block on chromosome 16p13 that includes KIAA0350. Three common non-coding variants of KIAA0350 in strong linkage disequilibrium reach genome-wide significance for association with the disease (PubMed:17632545). Belongs to the CLEC16A/gop-1 family. 3 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Unknown function Chromosomal Location of Human Ortholog: 16p13.13 Cellular Component: lysosomal membrane; endosome membrane Biological Process: autophagy |
| NCBI Summary: | This gene encodes a member of the C-type lectin domain containing family. Single nucleotide polymorphisms in introns of this gene have been associated with diabetes mellitus, multiple sclerosis and rheumatoid arthritis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011] |
| UniProt Code: | Q2KHT3 |
| NCBI GenInfo Identifier: | 54792782 |
| NCBI Gene ID: | 23274 |
| NCBI Accession: | NP_056041.1 |
| UniProt Secondary Accession: | Q2KHT3,O15058, Q6ZTB2, |
| UniProt Related Accession: | Q2KHT3 |
| Molecular Weight: | 14,283 Da |
| NCBI Full Name: | protein CLEC16A isoform 1 |
| NCBI Synonym Full Names: | C-type lectin domain family 16 member A |
| NCBI Official Symbol: | CLEC16A |
| NCBI Official Synonym Symbols: | Gop-1; KIAA0350 |
| NCBI Protein Information: | protein CLEC16A |
| UniProt Protein Name: | Protein CLEC16A |
| Protein Family: | Protein |
| UniProt Gene Name: | CLEC16A |
| UniProt Entry Name: | CL16A_HUMAN |
 | Western blot analysis of extracts of various cell lines, using CLEC16A antibody (CAB9753) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s. |
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