Signal Transduction Antibodies 3
Anti-TRPM8 Antibody (CAB4269)
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- SKU:
- CAB4269
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Signal Transduction
Description
| Antibody Name: | Anti-TRPM8 Antibody |
| Antibody SKU: | CAB4269 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human |
| Host Species: | Rabbit |
| Immunogen: | A synthesized peptide derived from human TRPM8 |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human |
| Positive Samples: | PC-3, MCF7 |
| Immunogen: | A synthesized peptide derived from human TRPM8 |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 79054 |
| Uniprot: | Q7Z2W7 |
| Cellular Location: | |
| Calculated MW: | 128kDa |
| Observed MW: | 110KDa |
| Synonyms: | LTRPC6, TRPP8 |
| Background: |
| UniProt Protein Function: | TRPM8: Receptor-activated non-selective cation channel involved in detection of sensations such as coolness, by being activated by cold temperature below 25 degrees Celsius. Activated by icilin, eucalyptol, menthol, cold and modulation of intracellular pH. Involved in menthol sensation. Permeable for monovalent cations sodium, potassium, and cesium and divalent cation calcium. Temperature sensing is tightly linked to voltage-dependent gating. Activated upon depolarization, changes in temperature resulting in graded shifts of its voltage-dependent activation curves. The chemical agonists menthol functions as a gating modifier, shifting activation curves towards physiological membrane potentials. Temperature sensitivity arises from a tenfold difference in the activation energies associated with voltage-dependent opening and closing. Belongs to the transient receptor (TC 1.A.4) family. LTrpC subfamily. TRPM8 sub-subfamily. 3 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Membrane protein, integral; Channel, cation; Membrane protein, multi-pass Chromosomal Location of Human Ortholog: 2q37.1 Cellular Component: plasma membrane Molecular Function:calcium channel activity; protein binding |
| UniProt Code: | Q7Z2W7 |
| NCBI GenInfo Identifier: | 143811469 |
| NCBI Gene ID: | 79054 |
| NCBI Accession: | Q7Z2W7.2 |
| UniProt Secondary Accession: | Q7Z2W7,Q3YFM7, Q6QNH9, Q8TAC3, Q8TDX8, Q9BVK1, A0AVG2 |
| UniProt Related Accession: | Q7Z2W7 |
| Molecular Weight: | 79,096 Da |
| NCBI Full Name: | Transient receptor potential cation channel subfamily M member 8 |
| NCBI Synonym Full Names: | transient receptor potential cation channel subfamily M member 8 |
| NCBI Official Symbol: | TRPM8 |
| NCBI Official Synonym Symbols: | TRPP8; LTRPC6 |
| NCBI Protein Information: | transient receptor potential cation channel subfamily M member 8 |
| UniProt Protein Name: | Transient receptor potential cation channel subfamily M member 8 |
| UniProt Synonym Protein Names: | Long transient receptor potential channel 6; LTrpC-6; LTrpC6; Transient receptor potential p8; Trp-p8 |
| Protein Family: | TRPM8 channel-associated factor |
| UniProt Gene Name: | TRPM8 |
| UniProt Entry Name: | TRPM8_HUMAN |
 | Western blot - TRPM8 Rabbit mAb (CAB4269) |
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