Enzymes Recombinant Proteins
Human AK5 Recombinant Protein (RPPB2434)
- SKU:
- RPPB2434
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- Q9Y6K8
- Research Area:
- Enzymes
Description
| Product Name: | Human AK5 Recombinant Protein |
| Product Code: | RPPB2434 |
| Size: | 10µg |
| Species: | Human |
| Target: | AK5 |
| Synonyms: | Adenylate kinase isoenzyme 5, AK 5, ATP-AMP transphosphorylase 5, AK5, AK6. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile filtered colorless solution. |
| Formulation: | AK5 protein solution (0.25mg/ml) containing 20mM Tris-HCl buffer (pH8.0), 20% glycerol and 1mM DTT. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 85% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MGSHMNTNDA KEYMARREIP QLFESLLNGL MCSKPEDPVE YLESCLQKVK ELGGCDKVKW DTFVSQEKKT LPPLNGGQSR RSFLRNVMPG NSNFPYRRYD RLPPIHQFSI ESDTDLSETA ELIEEYEVFD PTRPRPKIIL VIGGPGSGKG TQSLKIAERY GFQYISVGEL LRKKIHSTSS NRKWSLIAKI ITTGELAPQE TTITEIKQKL MQIPDEEGIV IDGFPRDVAQ ALSFEDQICT PDLVVFLACA NQRLKERLLK RAEQQGRPDD NVKATQRRLM NFKQNAAPLV KYFQEKGLIM TFDADRDEDE VFYDISMAVD NKLFPNKEAA AGSSDLDPSM ILDTGEIIDT GSDYEDQGDD QLNVFGEDTM GGFMEDLRKC KIIFIIGGPG SGKGTQCEKL VEKYGFTHLS TGELLREELA SESERSKLIR DIMERGDLVP SGIVLELLKE AMVASLGDTR GFLIDGYPRE VKQGEEFGRR IGDPQLVICM DCSADTMTNR LLQRSRSSLP VDDTTKTIAK RLEAYYRASI PVIAYYETKT QLHKINAEGT PEDVFLQLCT AIDSIF |
Adenylate kinase isoenzyme 5 (AK5) belongs to the adenylate kinase family, which is involved in regulating the adenine nucleotide composition within a cell by catalyzing the reversible transfer of phosphate groups among adenine nucleotides. AK5 is related to the UMP/CMP kinase of several species. AK5 is located in the cytosol and expressed exclusively in the brain.
AK5 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 586 amino acids (1-562 a.a.) and having a molecular mass of 65.9kDa.AK5 is fused to a 24 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
| UniProt Protein Function: | AK5: Active on AMP and dAMP with ATP as a donor. When GTP is used as phosphate donor, the enzyme phosphorylates AMP, CMP, and to a small extent dCMP. Belongs to the adenylate kinase family. 3 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Kinase, other; Nucleotide Metabolism - purine; EC 2.7.4.6; EC 2.7.4.3 Chromosomal Location of Human Ortholog: 1p31 Cellular Component: cytoplasm; cytosol; microtubule organizing center Molecular Function:nucleoside diphosphate kinase activity; nucleoside kinase activity Biological Process: ADP biosynthetic process; dADP biosynthetic process; nucleobase, nucleoside and nucleotide interconversion; nucleoside diphosphate phosphorylation; nucleoside triphosphate biosynthetic process; pyrimidine ribonucleotide biosynthetic process |
| NCBI Summary: | This gene encodes a member of the adenylate kinase family, which is involved in regulating the adenine nucleotide composition within a cell by catalyzing the reversible transfer of phosphate groups among adenine nucleotides. This member is related to the UMP/CMP kinase of several species. It is located in the cytosol and expressed exclusively in brain. Alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q9Y6K8 |
| NCBI GenInfo Identifier: | 257051028 |
| NCBI Gene ID: | 26289 |
| NCBI Accession: | Q9Y6K8.2 |
| UniProt Secondary Accession: | Q9Y6K8,Q5U622, Q6FH66, Q7Z4T5, Q86YS0, Q8N464, Q96EC9 |
| UniProt Related Accession: | Q9Y6K8 |
| Molecular Weight: | 60,315 Da |
| NCBI Full Name: | Adenylate kinase isoenzyme 5 |
| NCBI Synonym Full Names: | adenylate kinase 5 |
| NCBI Official Symbol: | AK5�� |
| NCBI Official Synonym Symbols: | AK6�� |
| NCBI Protein Information: | adenylate kinase isoenzyme 5 |
| UniProt Protein Name: | Adenylate kinase isoenzyme 5 |
| UniProt Synonym Protein Names: | ATP-AMP transphosphorylase 5 |
| Protein Family: | Adenylate kinase |
| UniProt Gene Name: | AK5�� |
| UniProt Entry Name: | KAD5_HUMAN |
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