CD Antigens Recombinant Proteins
Human CD33 Recombinant Protein (RPPB3063)
- SKU:
- RPPB3063
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- P20138
- Research Area:
- CD Antigens
Description
| Product Name: | Human CD33 Recombinant Protein |
| Product Code: | RPPB3063 |
| Size: | 20µg |
| Species: | Human |
| Target: | CD33 |
| Synonyms: | CD33Molecule, CD33Antigen (Gp67), Sialic AcidBinding Ig-Like Lectin 3, Sialic Acid-Binding Ig-Like Lectin 3, SIGLEC3, gp67, SIGLEC-3,Myeloid Cell Surface AntigenCD33, p67, Siglec-3, CD33Antigen. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered clear solution. |
| Formulation: | CD33 protein solution (1mg/ml) containing 20mM Tris-HClbuffer (pH 8.0), 0.4M Urea, and 10% glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time.For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please avoid freeze thaw cycles. |
| Purity: | Greaterthan 90% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MGSDPNFWLQ VQESVTVQEG LCVLVPCTFF HPIPYYDKNS PVHGYWFREG AIISGDSPVA TNKLDQEVQE ETQGRFRLLG DPSRNNCSLS IVDARRRDNG SYFFRMERGS TKYSYKSPQL SVHVTDLTHR PKILIPGTLE PGHSKNLTCS VSWACEQGTP PIFSWLSAAP TSLGPRTTHS SVLIITPRPQ DHGTNLTCQV KFAGAGVTTE RTIQLNVTYV PQNPTTGIFP GDGSGKQETR AGVVH |
CD33is putative adhesion molecule of myelomonocytic-derived cells which mediatessialic-acid dependent binding to cells. CD33 prefers to bind toalpha-2,6-linked sialic acid. The sialic acid recognition site is masked by cisinteractions with sialic acids on the same cell surface. In the immuneresponse, CD33 perform as an inhibitory receptor upon ligand induced tyrosinephosphorylation by recruiting cytoplasmic phosphatases through their SH2domains which block signal transduction through dephosphorylation of signalingmolecules. In addition, CD33 induces apoptosis in acutemyeloid leukemia.
CD33 Human Recombinant produced in E.Coli is a single,non-glycosylated polypeptide chain containing 265 amino acids (18-259 a.a) andhaving a molecular mass of 29.1kDa.CD33 is fused to a 23 amino acid His-tag at N-terminus& purified by proprietary chromatographic techniques.
| UniProt Protein Function: | CD33: Putative adhesion molecule of myelomonocytic-derived cells that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. In the immune response, may act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules. Induces apoptosis in acute myeloid leukemia (in vitro). Belongs to the immunoglobulin superfamily. SIGLEC (sialic acid binding Ig-like lectin) family. |
| UniProt Protein Details: | Protein type:Membrane protein, integral; Cell adhesion Chromosomal Location of Human Ortholog: 19q13.3 Cellular Component: integral to plasma membrane; plasma membrane; external side of plasma membrane Molecular Function:protein binding; receptor activity; carbohydrate binding Biological Process: negative regulation of cell proliferation; cell-cell signaling; signal transduction; cell adhesion |
| UniProt Code: | P20138 |
| NCBI GenInfo Identifier: | 116241290 |
| NCBI Gene ID: | 945 |
| NCBI Accession: | P20138.2 |
| UniProt Secondary Accession: | P20138,Q8TD24, B4E3P8, C9JEN7, F8WAL2, |
| UniProt Related Accession: | P20138 |
| Molecular Weight: | Calculated MW: 25kDa/33kDa/39kDaObserved MW: 77kDa |
| NCBI Full Name: | Myeloid cell surface antigen CD33 |
| NCBI Synonym Full Names: | CD33 molecule |
| NCBI Official Symbol: | CD33�� |
| NCBI Official Synonym Symbols: | p67; SIGLEC3; SIGLEC-3�� |
| NCBI Protein Information: | myeloid cell surface antigen CD33; gp67; CD33 antigen (gp67); sialic acid binding Ig-like lectin 3; sialic acid-binding Ig-like lectin 3 |
| UniProt Protein Name: | Myeloid cell surface antigen CD33 |
| UniProt Synonym Protein Names: | Sialic acid-binding Ig-like lectin 3; Siglec-3; gp67; CD_antigen: CD33 |
| Protein Family: | Myeloid cell surface antigen |
| UniProt Gene Name: | CD33�� |
| UniProt Entry Name: | CD33_HUMAN |
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