Chemokines Recombinant Proteins

Human CTACK Recombinant Protein (RPPB1111)

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SKU:
RPPB1111
Product Type:
Recombinant Protein
Species:
Human
Uniprot:
Q9Y4X3
Research Area:
Chemokines

Description

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Product Name:Human CTACK Recombinant Protein
Product Code:RPPB1111
Size:20µg
Species:Human
Target:CTACK
Synonyms:ALP, CTACK, ESKINE, ILC, PESKY, SCYA27, CCL27, C-C motif chemokine 27, Small-inducible cytokine A27, IL-11 R-alpha-locus chemokine, Skinkine, ESkine, Cutaneous T-cell-attracting chemokine.
Source:Escherichia Coli
Physical Appearance:Sterile filtered colorless solution.
Formulation:CTACK Human solution containing 10mM sodium citrate pH-3.5 & 10% glycerol.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 95% as determined by SDS-PAGE.
Amino Acid Sequence:MFLLPPSTAC CTQLYRKPLS DKLLRKVIQV ELQEADGDCH LQAFVLHLAQ RSICIHPQNP SLSQWFEHQE RKLHGTLPKL NFGMLRKMG

CTACK is a chemotactic factor that attracts skin-associated memory T-lymphocytes. CTACK is involved in mediating homing of lymphocytes to cutaneous sites. CTACK Binds to CCR10.

CTACK Human Recombinant produced in E.Coli is a single, non-glycosylated,polypeptide chain containing 89 amino acids (25-112 a.a.) and having a molecular mass of 10.3kDa. CTACK protein is purified by standard chromatography.

UniProt Protein Function:CCL27: Chemotactic factor that attracts skin-associated memory T-lymphocytes. May play a role in mediating homing of lymphocytes to cutaneous sites. May play a role in cell migration during embryogenesis. Nuclear forms may facilitate cellular migration by inducing cytoskeletal relaxation. Binds to CCR10. Belongs to the intercrine beta (chemokine CC) family.
UniProt Protein Details:

Protein type:Secreted; Secreted, signal peptide; Motility/polarity/chemotaxis; Chemokine

Chromosomal Location of Human Ortholog: 9p13

Cellular Component: extracellular space; extracellular region

Molecular Function:chemokine activity

Biological Process: cell-cell signaling; immune response; chemotaxis

NCBI Summary:This gene is one of several CC cytokine genes clustered on the p-arm of chromosome 9. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The protein encoded by this gene is chemotactic for skin-associated memory T lymphocytes. This cytokine may also play a role in mediating homing of lymphocytes to cutaneous sites. It specifically binds to chemokine receptor 10 (CCR10). Studies of a similar murine protein indicate that these protein-receptor interactions have a pivotal role in T cell-mediated skin inflammation. [provided by RefSeq, Sep 2014]
UniProt Code:Q9Y4X3
NCBI GenInfo Identifier:7674366
NCBI Gene ID:10850
NCBI Accession:Q9Y4X3.1
UniProt Related Accession:Q9Y4X3
Molecular Weight:12,618 Da
NCBI Full Name:C-C motif chemokine 27
NCBI Synonym Full Names:chemokine (C-C motif) ligand 27
NCBI Official Symbol:CCL27��
NCBI Official Synonym Symbols:ALP; ILC; CTAK; CTACK; PESKY; ESKINE; SCYA27��
NCBI Protein Information:C-C motif chemokine 27; skinkine; CC chemokine ILC; IL-11 Ralpha-locus chemokine; small-inducible cytokine A27; IL-11 R-alpha-locus chemokine; cutaneous T-cell attracting chemokine; cutaneous T-cell-attracting chemokine; small inducible cytokine subfamily A (Cys-Cys), member 27
UniProt Protein Name:C-C motif chemokine 27
UniProt Synonym Protein Names:CC chemokine ILC; Cutaneous T-cell-attracting chemokine; CTACK; ESkine; IL-11 R-alpha-locus chemokine; Skinkine; Small-inducible cytokine A27
Protein Family:C-C motif chemokine
UniProt Gene Name:CCL27��
UniProt Entry Name:CCL27_HUMAN
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