Cytokines Recombinant Proteins

Human CYTL1 Recombinant Protein (RPPB0154)

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SKU:
RPPB0154
Product Type:
Recombinant Protein
Species:
Human
Uniprot:
Q9NRR1
Research Area:
Cytokines

Description

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Product Name:Human CYTL1 Recombinant Protein
Product Code:RPPB0154
Size:10µg
Species:Human
Target:CYTL1
Synonyms:Cytokine-like protein 1, Protein C17, CYTL1, C4orf4, C17.
Source:Escherichia Coli
Physical Appearance:Filtered White lyophilized (freeze-dried) powder.
Formulation:CYTL1 was filtered (0.4 �m) and lyophilized from 0.5mg/ml in 20mM Tris buffer and 50mM NaCl, pH 7.5.
Solubility:It is recommended to add 200�l deionized water to prepare a working stock solution of approximately 0.5 mg/ml and let the lyophilized pellet dissolve completely. CYTL1 is not sterile! Please filter the product by an appropriate sterile filter before using it in the cell culture.
Stability:Store lyophilized protein at -20°C. Aliquot the product after reconstitution to avoid repeated freezing/thawing cycles. Reconstituted protein can be stored at 4°C for a limited period of time; it does not show any change after two weeks at 4°C.
Purity:Greater than 95.0% as determined by SDS-PAGE.
Amino Acid Sequence:MKHHHHHHASTPPTCYSRMR ALSQEITRDF NLLQVSEPSE PCVRYLPRLY LDIHNYCVLD KLRDFVASPP CWKVAQVDSL KDKARKLYTI MNSFCRRDLV FLLDDCNALE YPIPVTTVLP DRQR

Cytokine-like protein 1 (CYTL1) is a secreted protein. CYTL1 is expressed in CD34+ cell populations of bone marrow and cord blood which function as hematopoietic stem/progenitor cells. However, CYTL1 is not expressed in CD34- cells. Experiments with knock-out mice (Cytl1-/-) propose that CYTL1 is essential for the maintenance of cartilage homeostasis rather than cartilage and bone development, and loss of CYTL1 function is linked with experimental osteoarthritic cartilage destruction in mice.

CYTL1 Human Recombinant produced in E.Coli is a single, non-glycosylated, polypeptide chain (aa 23-136) containing 124 amino acids including a 10 a.a N-terminal His tag. The total molecular mass is 14.6kDa (calculated).

UniProt Protein Function:
UniProt Protein Details:
NCBI Summary:C17 is a cytokine-like protein specifically expressed in bone marrow and cord blood mononuclear cells that bear the CD34 (MIM 142230) surface marker (Liu et al., 2000 [PubMed 10857752]).[supplied by OMIM, Mar 2008]
UniProt Code:Q9NRR1
NCBI GenInfo Identifier:8922108
NCBI Gene ID:54360
NCBI Accession:NP_061129.1
UniProt Secondary Accession:Q9NRR1
UniProt Related Accession:Q9NRR1
Molecular Weight:16 kDa
NCBI Full Name:cytokine-like protein 1
NCBI Synonym Full Names:cytokine like 1
NCBI Official Symbol:CYTL1��
NCBI Official Synonym Symbols:C17; C4orf4��
NCBI Protein Information:cytokine-like protein 1
UniProt Protein Name:Cytokine-like protein 1
UniProt Synonym Protein Names:Protein C17
Protein Family:
UniProt Gene Name:CYTL1��
UniProt Entry Name:
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