Fibroblast growth factor 10 (FGF-10/KGF-2), is a member of the fibroblast growth factor (FGF) family that includes FGF-3, -7, and -22. Mesenchymal cells secrete FGF-10 and collaborate with extracellular FGF-BP. It binds and activates epithelial cell FGFR2 more strongly than it binds and activates FGFR1. FGF-10 is an important regulator of embryonic development, cell proliferation, and cellular differentiation. It has mitogenic activity for keratinizing epidermal cells, but no activity for fibroblasts, which is comparable to that of FGF7. FGF10 is essential for proper branching morphogenesis. Autosomal dominant aplasia of the lacrimal and salivary glands (ALSG) is caused by FGF10 abnormalities. Affected individuals may have apical aplasia or hypoplasia of the lacrimal, parotid, submandibular, and sublingual glands with no lacrimal puncta. The disorder is characterized by irritable eyes, recurrent eye infections, epiphora (constant tearing) and xerostomia (dryness of the mouth), which increases the risk of dental erosion, dental caries, periodontal disease and oral infections.
Recombinant Human Fibroblast Growth Factor 10 is produced by our E.coli expression system and the target gene encoding Gln38-Ser208 is expressed.
Purity:
> 95 % as determined by reducing SDS-PAGE.
Mol Mass:
19.5 kDa
AP Mol Mass:
19 kDa
Formulation:
Lyophilized from a 0.2 µm filtered solution of 20mM Tris,200mM NaCl,pH8.0.
Shipping:
This product is provided as lyophilized powder which is shipped with ice packs.
Stability and Storage:
Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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