Human RBL1 / Retinoblastoma-like protein 1 ELISA Kit

(No reviews yet) Write a Review
SKU:
HUFI01114
Product Type:
ELISA Kit
Size:
96 Assays
Uniprot:
P28749
Sensitivity:
0.938ng/ml
Range:
1.563-100ng/ml
ELISA Type:
Sandwich
Synonyms:
RBL1, Retinoblastoma-like protein 1, 107 kDa retinoblastoma-associated protein, p107
Reactivity:
Human
Research Area:
Cell Cycle

Description

Human RBL1 / Retinoblastoma-like protein 1 ELISA Kit

The protein encoded by RBL1/Retinoblastoma-like protein 1 is similar to the retinoblastoma 1 (RB1) gene's product in sequence and possibly function. The RB1 gene product appears to be involved in cell cycle regulation, as it is phosphorylated during the S to M phase transition and dephosphorylated during the G1 phase of the cell cycle. Adenovirus E1A protein and SV40 large T-antigen can form a complex with both the RB1 protein and the product of this gene, with the SV40 large T-antigen binding only to the unphosphorylated form of each protein. Both proteins have the ability to prevent the transcription of cell cycle genes with E2F binding sites in their promoters. The protein encoded by RBL1/Retinoblastoma-like protein 1 is thought to be a tumour suppressor due to sequence and biochemical similarities with the RB1 protein. Retinoblastoma and Bilateral Retinoblastoma are two diseases linked to RBL1.

View AllClose

0 Reviews

View AllClose