Human Tubulin Polymerization Promoting ProteinTPPP / TPPP ELISA Kit

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SKU:
HUFI02920
Product Type:
ELISA Kit
Size:
96 Assays
Uniprot:
O94811
Sensitivity:
0.375ng/ml
Range:
0.625-40ng/ml
ELISA Type:
Sandwich
Synonyms:
TPPP
Reactivity:
Human
Research Area:
Cell Cycle

Description

Human Tubulin Polymerization Promoting ProteinTPPP / TPPP ELISA

Tubulin polymerization promoting protein TPPP (TPPP) is a protein-coding gene that is a regulator of microtubule dynamics, which plays a key role in myelination by promoting elongation of the myelin sheath. TPPP also acts as a microtubule nucleation factor in oligodendrocytes. It localises to the postsynaptic Golgi apparatus region, also known as the Golgi outpost. This also promotes microtubule nucleations. This is an essential step for elongation of the myelin sheath. In addition, both uniform polarization of distal microtubules and the branching of proximal processes are regulated by TPPP. TPPP also controls microtubule dynamics by promoting tubulin acetylation, which is achieved through the inhibition of HDAC6's tubulin deacetylase activity. TPPP also regulates cell migration through the mechanism of phosphorylation by ROCK1 inhibits interaction with HDAC6. This results in a decrease in the levels of acetylation of tubulin and increased levels of cell motility. Cell proliferation is influenced by TPPP which plays a role in G12-phase transition. In the early stages of mitosis, TPPP plays a role in astral microtubule organisation and mitotic spindle orientation. overall this process is regulated through phosphorylation by LIMK2. TPPP shows magnesium-dependent GTPase activity although the role of the GTPase activity remains unclear. TPPP maintains the integrity of the microtubule network by playing a role in microtubule bundling and stabilization of existing microtubules. Auto-dominant non-syndromic intellectual disability 3 and spinocerebellar ataxia 27 are two examples of diseases caused by TPPP. Sudden infant death syndrome (SIDS) susceptibility pathways and glial cell differentiation are pathways associated with TPPP. Microtubule binding and tubulin binding are related to TPPP, according to gene ontology annotations. TPPP3 is a paralog of TPPP.

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