Human WIF1 Recombinant Protein (RPPB5935)
- SKU:
- RPPB5935
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- Q9Y5W5
Description
| Product Name: | Human WIF1 Recombinant Protein |
| Product Code: | RPPB5935 |
| Size: | 5µg |
| Species: | Human |
| Target: | WIF1 |
| Synonyms: | WIF1, WIF-1, Wnt inhibitory factor 1. |
| Source: | Hi-5 cells |
| Physical Appearance: | Sterile filtered colorless solution. |
| Formulation: | The WIF1 protein solution contains 1X PBS pH 7.4, 10% glycerol and 1mM PMSF. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time.For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 80.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | ADLGPPQEES LYLWIDAHQA RVLIGFEEDI LIVSEGKMAP FTHDFRKAQQ RMPAIPVNIH SMNFTWQAAG QAEYFYEFLS LRSLDKGIMA DPTVNVPLLG TVPHKASVVQ VGFPCLGKQD GVAAFEVDVI VMNSEGNTIL KTPQNAIFFK TCQQAECPGG CRNGGFCNER RICECPDGFH GPHCEKALCT PRCMNGGLCV TPGFCICPPG FYGVNCDKAN CSTTCFNGGT CFYPGKCICP PGLEGEQCEI SKCPQPCRNG GKCIGKSKCK CSKGYQGDLC SKPVCEPGCG AHGTCHEPNK CQCQEGWHGR HCNKRYEASL IHALRPAGAQ LRQHTPSLKK AEERRDPPES NYIWSGRLVP RGSHHHHHH |
WIF1 binds to wnt proteins and inhibits their activities. WIF1 plays a role in mesoderm segmentation. WNT proteins are extracellular signaling molecules that take part in the control of embryonic development & cancer. WIF1 protein contains a WNT inhibitory factor (WIF) domain and 5 epidermal growth factor (EGF)-like domains. WIF1 takes part in mesoderm segmentation. WIF1 protein is found to be present in fish, amphibia and mammals. WIF1 is a recurrent target in human salivary gland oncogenesis. Downregulation of WIF1 takes part in the development and progression of pleomorphic adenomas. WIF1 is a tumor suppressor, specifically in nonfunctioning pituitary tumors.
WIF1 produced in Hi-5 cells is a single, glycosylated polypeptide chain containing 369 amino acids (29-379 a.a.) and having a molecular mass of 40.5 kDa, (48kDa on SDS-PAGE). WIF1 is fused to 16 amino acid His Tag at C-Terminus and purified by proprietary chromatographic techniques.
| UniProt Protein Function: | WIF1: Binds to WNT proteins and inhibits their activities. May be involved in mesoderm segmentation. |
| UniProt Protein Details: | Protein type:Inhibitor; Secreted, signal peptide; Secreted Chromosomal Location of Human Ortholog: 12q14.3 Molecular Function:protein binding |
| NCBI Summary: | The protein encoded by this gene functions to inhibit WNT proteins, which are extracellular signaling molecules that play a role in embryonic development. This protein contains a WNT inhibitory factor (WIF) domain and five epidermal growth factor (EGF)-like domains, and is thought to be involved in mesoderm segmentation. This gene functions as a tumor suppressor gene, and has been found to be epigenetically silenced in various cancers. [provided by RefSeq, Jun 2010] |
| UniProt Code: | Q9Y5W5 |
| NCBI GenInfo Identifier: | 61252765 |
| NCBI Gene ID: | 11197 |
| NCBI Accession: | Q9Y5W5.3 |
| UniProt Secondary Accession: | Q9Y5W5,Q6UXI1, Q8WVG4, |
| UniProt Related Accession: | Q9Y5W5 |
| Molecular Weight: | 41,528 Da |
| NCBI Full Name: | Wnt inhibitory factor 1 |
| NCBI Synonym Full Names: | WNT inhibitory factor 1 |
| NCBI Official Symbol: | WIF1�� |
| NCBI Official Synonym Symbols: | WIF-1�� |
| NCBI Protein Information: | wnt inhibitory factor 1 |
| UniProt Protein Name: | Wnt inhibitory factor 1 |
| Protein Family: | Wnt inhibitory factor |
| UniProt Gene Name: | WIF1�� |
| UniProt Entry Name: | WIF1_HUMAN |
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