Signaling Pathway Assays

Monoamine Oxidase Inhibitor Screening Kit (BA0188)

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SKU:
BA0188
Product Type:
Assay
Instrument:
Microplate Reader
Sample Type:
Monoaime Oxidase
Research Area:
Oxidative Stress
Research Area:
Reactive Oxygen Species
Research Area:
High-Throughput Screening

Description

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About Monoamine Oxidases (MAO):

MONOAMINE OXIDASES (MAO, EC 1.4.3.4) are a family of mitochondrial enzymes that catalyze the oxidative deamination of monoamines. Two isoforms of MAO exist, MAO-A and MAO-B, with different inhibitor selectivity and tissue distribution. MAO dysfunction is thought to be responsible for a number of neurological disorders. Unusually high or low levels of MAOs in the body have been associated with depression, schizophrenia, substance abuse, attention deficit disorder, migraines, and irregular sexual maturation. MAO inhibitors are one of the major classes of drug prescribed for the treatment of depression, Parkinson's and Alzheimer's diseases.

How our MAO Inhibitor Screening Assay Kit Works:

 Assay Genie's MAO Inhibitor Screening Assay Kit provides a convenient fluorimetric means to screen for MAO enzyme inhibitors. In the assay, MAO reacts with p-tyramine, a substrate for both MAO-A and MAO-B, resulting in the formation of H2O2, which is determined by a fluorimetric method (λem/ex = 585/530 nm). The assay is simple, sensitive, stable and high-throughput adaptable.

Key Features:

  • Homogeneous and convenient. "Mix-incubate-measure" type assay.
  • No wash and reagent transfer steps are involved.

MAO Inhibitor Screening Assay Kit Information:

Application: HTS for inhibitor screening and evaluation of monoamine oxidase inhibitors.
Method: FL530/585nm
Sample: Monoamine Oxidase
Species: All
Procedure: 35 minutes
Size: 100 tests
Shelf Life: 6 months
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