Cardiovascular Recombinant Proteins

Mouse ANGPTL4 Recombinant Protein (RPES4808)

(No reviews yet) Write a Review
SKU:
RPES4808
Product Type:
Recombinant Protein
Species:
Mouse
Research Area:
Cardiovascular

Description

system_update_altDatasheet

Mouse ANGPTL4 Recombinant Protein

Angiopoietin-related protein 4?ANGPTL4?is a secreted protein and contains 1 fibrinogen C-terminal domain. The protein may act as a regulator of angiogenesis and modulate tumorigenesis. It inhibits proliferation, migration, and tubule formation of endothelial cells and reduces vascular leakage. ANGPTL4 may exert a protective function on endothelial cells through an endocrine action. It is directly involved in regulating glucose homeostasis, lipid metabolism, and insulin sensitivity (By similarity). In response to hypoxia, the unprocessed form of the protein accumulates in the subendothelial extracellular matrix (ECM). The matrix-associated and immobilized unprocessed form limits the formation of actin stress fibers and focal contacts in the adhering endothelial cells and inhibits their adhesion. It also decreases motility of endothelial cells and inhibits the sprouting and tube formation.

View AllClose

0 Reviews

View AllClose