Cytokines Recombinant Proteins

Mouse IL36B Recombinant Protein (RPPB0683)

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SKU:
RPPB0683
Product Type:
Recombinant Protein
Species:
Mouse
Uniprot:
Q9D6Z6
Research Area:
Cytokines

Description

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Product Name:Mouse IL36B Recombinant Protein
Product Code:RPPB0683
Size:10µg
Species:Mouse
Target:IL36B
Synonyms:Interleukin 36 beta, interleukin 1 family member 8 (eta), Interleukin-1 homolog 2, IL1F8 (Canonical product IL-1F8a), IL-1F8 (FIL1-eta), Interleukin-1 Superfamily e, IL1H2, MGC126880, MGC126882.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered White lyophilized (freeze-dried) powder.
Formulation:Lyophilized from a 0.2�m filtered concentrated solution in 1�PBS, pH 7.4.
Solubility:It is recommended to reconstitute the lyophilized IL36B in sterile 18M-cm H2O not less than 100�g/ml, which can then be further diluted to other aqueous solutions.
Stability:Lyophilized IL36B Mouse although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution IL36B should be stored at 4°C between 2-7 days and for future use below -18°C.Please prevent freeze-thaw cycles.
Purity:Greater than 95.0% as determined by SDS-PAGE.
Amino Acid Sequence:MMAFPPQSCV HVLPPKSIQM WEPNHNTMHG SSQSPRNYRV HDSQQMVWVL TGNTLTAVPA SNNVKPVILS LIACRDTEFQ DVKKGNLVFL GIKNRNLCFC CVEMEGKPTL QLKEVDIMNL YKERKAQKAF LFYHGIEGST SVFQSVLYPG WFIATSSIER QTIILTHQRG KLVNTNFYIE SEK
Biological Activity:Measured by its binding ability in a functional ELISA to bind recombinant mouse IL-1 Rrp2.

Mouse IL-36b belongs to the IL-1 family that includes IL-1b, IL-1a, IL-1ra, IL-18, IL-36ra (IL1F5), IL-36b (IL1F8), IL-36g (IL1F9), IL-37 (IL1F7) and IL-38 (IL-1F10). The IL-1 family members display a 12 b-strand, b-trefoil configuration, and are thought to have ascended from a mutual ancestral gene. Mouse IL-36b/IL-1F8 is a 183 amino acid protein which holds no signal sequence, no prosegment and no potential N-linked glycosylation site(s). Mouse IL-36b like its human homologue is actively secreted. Mouse IL-36k/IL-1F8 shares 61-74% aa homology with human IL-36k/IL-1F8 isoform 2 and rat IL-1F8.

IL36B Mouse Recombinant produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 183 amino acids and having a molecular mass of 21.0kDa.The IL36B is purified by proprietary chromatographic techniques.

UniProt Protein Function:IL36B: Stimulates production of interleukin-6 and interleukin-8 in synovial fibrobasts, articular chondrocytes and mature adipocytes. Induces expression of a number of antimicrobial peptides including beta-defensins 4 and 103 as well as a number of matrix metalloproteases. Belongs to the IL-1 family. 2 isoforms of the human protein are produced by alternative splicing.Protein type: CytokineCellular Component: extracellular region; extracellular spaceMolecular Function: cytokine activity; interleukin-1 receptor bindingBiological Process: cytokine and chemokine mediated signaling pathway; immune response; immune system process; inflammatory response; inflammatory response to antigenic stimulus; innate immune response; positive regulation of cytokine production; positive regulation of interleukin-6 production; positive regulation of T cell differentiation
UniProt Protein Details:
NCBI Summary:
UniProt Code:Q9D6Z6
NCBI GenInfo Identifier:118601193
NCBI Gene ID:69677
NCBI Accession:NP_081439.1
UniProt Secondary Accession:Q9D6Z6,Q8R461
UniProt Related Accession:Q9D6Z6
Molecular Weight:20,878 Da
NCBI Full Name:interleukin-36 beta
NCBI Synonym Full Names:interleukin 1 family, member 8
NCBI Official Symbol:Il1f8��
NCBI Official Synonym Symbols:Il36b; 2310043N20Rik��
NCBI Protein Information:interleukin-36 beta
UniProt Protein Name:Interleukin-36 beta
UniProt Synonym Protein Names:Interleukin-1 family member 8; IL-1F8
Protein Family:Interleukin
UniProt Gene Name:Il36b��
UniProt Entry Name:IL36B_MOUSE
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