Mouse LUM Recombinant Protein (RPPB5903)
- SKU:
- RPPB5903
- Product Type:
- Recombinant Protein
- Species:
- Mouse
- Uniprot:
- P51885
Description
| Product Name: | Mouse LUM Recombinant Protein |
| Product Code: | RPPB5903 |
| Size: | 10µg |
| Species: | Mouse |
| Target: | LUM |
| Synonyms: | Lum, Ldc, SLRR2D, Lumican, Keratan sulfate proteoglycan lumican, KSPG lumican. |
| Source: | Sf9 Insect cells |
| Physical Appearance: | Sterile Filtered colorless solution. |
| Formulation: | LUM protein solution (0.5mg/ml) containing Phosphate Buffered Saline (pH 7.4) and 20% glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greaterthan 95.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | QYYDYDIPLF MYGQISPNCA PECNCPHSYP TAMYCDDLKL KSVPMVPPGI KYLYLRNNQIDHIDEKAFEN VTDLQWLILD LLENSKIK GKVFSKLKQL KKLHINYNNL TESVGPLPKSLQDLQLTNNK ISKLGSFDGL VNLTFIYLQH NQLKEDAVSA SLKGLKSLEY LDLSFNQMSKLPAGLPTSLL TLYLDNNKIS NIPDEYFKRF TGLQYLRLSH NELADSGVPG NSFNISSLLELDLSYNKLKS IPTVNENLEN YYLEVNELEK FDVKSFCKIL GPLSYSKIKH LRLDGNPLTQ SSLPPDMYEC LRVANEITVN VEHHHHHH |
Lumican also known as LUM is a part of the small leucine-rich proteoglycan (SLRP) family which comprises decorin, biglycan, fibromodulin, keratocan, epiphycan, and osteoglycin. Furthermore, we can see that in these bifunctional molecules, the protein moiety binds collagen fibrils and the highly charged hydrophilic glycosaminoglycans regulate interfibrillar spacings. Lumican is the main keratan sulfate proteoglycan of the cornea however LUM is also distributed in interstitial collagenous matrices throughout the body. Lumican regulates collagen fibril organization and circumferential growth, corneal transparency, epithelial cell migration and tissue repair.
LUM Mouse Recombinant produced in Sf9 Baculovirus cells is a single, glycosylated polypeptide chain containing 328 amino acids (19-338 a.a) and having a molecular mass of 37.5kDa (Migrates at 40-57kDa on SDS-PAGE under reducing conditions).LUM is fused to an 8 amino acid His-tag at C-terminus & purified by proprietary chromatographic techniques.
| UniProt Protein Function: | LUM: a member of the small leucine-rich proteoglycan (SLRP) family that includes decorin, biglycan, fibromodulin, keratocan, epiphycan, and osteoglycin. In these bifunctional molecules, the protein moiety binds collagen fibrils and the highly charged hydrophilic glycosaminoglycans regulate interfibrillar spacings. Lumican is the major keratan sulfate proteoglycan of the cornea but is also distributed in interstitial collagenous matrices throughout the body. Lumican may regulate collagen fibril organization and circumferential growth, corneal transparency, and epithelial cell migration and tissue repair. [provided by RefSeq, Jul 2008] |
| UniProt Protein Details: | Protein type:Secreted, signal peptide; Secreted Cellular Component: extracellular matrix; proteinaceous extracellular matrix; extracellular space; fibrillar collagen; extracellular region Molecular Function:collagen binding Biological Process: collagen fibril organization; visual perception; positive regulation of transcription from RNA polymerase II promoter |
| UniProt Code: | P51885 |
| NCBI GenInfo Identifier: | 21542415 |
| NCBI Gene ID: | 17022 |
| NCBI Accession: | P51885.2 |
| UniProt Secondary Accession: | P51885,Q3TP25, Q99JZ3, Q9CXK0, |
| UniProt Related Accession: | P51885 |
| Molecular Weight: | 38,265 Da |
| NCBI Full Name: | Lumican |
| NCBI Synonym Full Names: | lumican |
| NCBI Official Symbol: | Lum�� |
| NCBI Official Synonym Symbols: | Ldc; SLRR2D�� |
| NCBI Protein Information: | lumican; KSPG lumican; keratan sulfate proteoglycan lumican |
| UniProt Protein Name: | Lumican |
| UniProt Synonym Protein Names: | Keratan sulfate proteoglycan lumican; KSPG lumican |
| Protein Family: | Lumican |
| UniProt Gene Name: | Lum�� |
| UniProt Entry Name: | LUM_MOUSE |
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